Case-Control Study Comparing De Novo and Daptomycin-Exposed Daptomycin-Nonsusceptible Enterococcus Infections

被引：18

作者：

Kelesidis, Theodoros ^{[1
]}

Chow, Angela L. P. ^{[2
,3
]}

Humphries, Romney ^{[4
]}

Uslan, Daniel Z. ^{[1
]}

Pegues, David ^{[1
]}

机构：

[1] Univ Calif Los Angeles, David Geffen Sch Med, Dept Med, Div Infect Dis, Los Angeles, CA 90095 USA

[2] Univ Calif Los Angeles, Sch Publ Hlth, Dept Epidemiol, Los Angeles, CA 90024 USA

[3] Tan Took Seng Hosp, Dept Clin Epidemiol, Novena, Singapore

[4] Univ Calif Los Angeles, David Geffen Sch Med, Dept Pathol & Lab Med, Los Angeles, CA 90095 USA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2012年 / 56卷 / 04期

关键词：

VANCOMYCIN;

D O I：

10.1128/AAC.05918-11

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Understanding factors associated with de novo daptomycin-nonsusceptible Enterococcus (DNSE) infections will aid in better understanding the mechanisms of daptomycin nonsusceptibility. We conducted a case-control study to compare patients with DNSE infections who were daptomycin treatment naive (n = 9) and those with DNSE infections who had exposure to daptomycin (n = 13). Less frequent exposure to antimicrobials, increased susceptibility to nitrofurantoin and gentamicin, and shorter duration of hospitalization were associated with de novo DNSE infection, suggesting a potential community reservoir.

引用

页码：2150 / 2152

页数：3

共 12 条

[1]

[Anonymous], 2011, Performance standards for antimicrobial disk susceptibility tests

[2]

approved standard M2-A11, V11th

[3] Comparison of three PCR primer sets for identification of vanB gene carriage in feces and correlation with carriage of vancomycin-resistant enterococci:: Interference by vanB-containing anaerobic bacilli [J].