Sc(OTf)3-Mediated One-Pot Synthesis of 2,3-Disubstituted Quinolines from Anilines and Epoxides

被引：16
|
作者：
Al Mehedi, Md Shafaat [1 ]
Tepe, Jetze J. [1 ]
机构：
[1] Michigan State Univ, Dept Chem, E Lansing, MI 48823 USA
来源：
JOURNAL OF ORGANIC CHEMISTRY | 2020年 / 85卷 / 10期
基金：
美国国家卫生研究院;
关键词：
3-COMPONENT SYNTHESIS; FUNCTIONALIZATION; QUINAZOLINE; ANNULATION; ALDEHYDE; ACCESS; BONDS;
D O I：
10.1021/acs.joc.0c00803
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Here, we report the first synthesis of 2,3-disubstituted quinolines from anilines and aromatic or aliphatic epoxides. This reaction utilizes Sc(OTf)(3) as a Lewis acid and TEMPO as an oxygen scavenger. A wide variety of highly substituted quinolines were obtained with moderate to excellent yields (up to 96%).
引用
收藏
页码：6741 / 6746
页数：6
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