Sphingosine 1-phosphate signaling impacts lymphocyte migration, inflammation and infection

被引：42

作者：

Tiper, Irina V. ^{[1
,2
]}

East, James E. ^{[1
,2
]}

Subrahmanyam, Priyanka B. ^{[1
,2
]}

Webb, Tonya J. ^{[1
,2
]}

机构：

[1] Univ Maryland, Sch Med, Dept Microbiol & Immunol, 685 W Baltimore St, Baltimore, MD 21201 USA

[2] Marlene & Stewart Greenebaum Canc Ctr, 685 W Baltimore St, Baltimore, MD 21201 USA

来源：

PATHOGENS AND DISEASE | 2016年 / 74卷 / 06期

基金：

美国国家卫生研究院;

关键词：

sphingosine; S1P; FTY720; lymphocyte trafficking; CIRCULATING MATURE LYMPHOCYTES; MULTIPLE-MYELOMA CELLS; LYSOPHOSPHATIDIC ACID; T-CELLS; CYTOKINE PRODUCTION; IN-VITRO; B-CELLS; SPHINGOSINE-1-PHOSPHATE; FTY720; KINASE;

D O I：

10.1093/femspd/ftw063

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Sphingosine 1-phosphate (S1P) is a sphingosine containing lipid intermediate obtained from ceramide. S1P is known to be an important signaling molecule and plays multiple roles in the context of immunity. This lysophospholipid binds and activates G-protein-coupled receptors (GPCRs) known as S1P receptors 1-5 (S1P(1-5)). Once activated, these GPCRs mediate signaling that can lead to alterations in cell proliferation, survival or migration, and can also have other effects such as promoting angiogenesis. In this review, we will present evidence demonstrating a role for S1P in lymphocyte migration, inflammation and infection, as well as in cancer. The therapeutic potential of targeting S1P receptors, kinases and lyase will also be discussed.

引用

页数：9

共 86 条

[1] Sphingosine kinase 1 is up-regulated during hypoxia in U87MG glioma cells [J].

Anelli, Viviana ;

Gault, Christopher R. ;

Cheng, Amy B. ;

Obeid, Lina M. .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2008, 283 (06) :3365-3375

[2] Targeting NFκB mediated breast cancer chemoresistance through selective inhibition of sphingosine kinase-2 [J].

Antoon, James W. ;

White, Martin D. ;

Slaughter, Evelyn M. ;

Driver, Jennifer L. ;

Khalili, Hafez S. ;

Elliott, Steven ;

Smith, Charles D. ;

Burow, Matthew E. ;

Beckman, Barbara S. .

CANCER BIOLOGY & THERAPY, 2011, 11 (07) :678-689

[3] Sphingosine-1-phosphate signaling: unraveling its role as a drug target against infectious diseases [J].

Arish, Mohd ;

Husein, Atahar ;

Kashif, Mohammad ;

Saleem, Mohammed ;

Akhter, Yusuf ;

Rub, Abdur .

DRUG DISCOVERY TODAY, 2016, 21 (01) :133-142

[4] Exit Strategies: S1P Signaling and T Cell Migration [J].

Baeyens, Audrey ;

Fang, Victoria ;

Chen, Cynthia ;

Schwab, Susan R. .

TRENDS IN IMMUNOLOGY, 2015, 36 (12) :778-787

[5] Novel S1P1 Receptor Agonists - Part 3: From Thiophenes to Pyridines [J].

Bolli, Martin H. ;

Abele, Stefan ;

Birker, Magdalena ;

Bravo, Roberto ;

Bur, Daniel ;

de Kanter, Ruben ;

Kohl, Christopher ;

Grimont, Julien ;

Hess, Patrick ;

Lescop, Cyrille ;

Mathys, Boris ;

Mueller, Claus ;

Nayler, Oliver ;

Rey, Markus ;

Scherz, Michael ;

Schmidt, Gunther ;

Seifert, Juergen ;

Steiner, Beat ;

Velker, Joerg ;

Weller, Thomas .

JOURNAL OF MEDICINAL CHEMISTRY, 2014, 57 (01) :110-130

[6] FTY720: Altered lymphocyte traffic results in allograft protection. [J].

Brinkmann, V ;

Pinschewer, DD ;

Feng, L ;

Chen, S .

TRANSPLANTATION, 2001, 72 (05) :764-769

[7] Fingolimod (FTY720): discovery and development of an oral drug to treat multiple sclerosis [J].

Brinkmann, Volker ;

Billich, Andreas ;

Baumruker, Thomas ;

Heining, Peter ;

Schmouder, Robert ;

Francis, Gordon ;

Aradhye, Shreeram ;

Burtin, Pascale .

NATURE REVIEWS DRUG DISCOVERY, 2010, 9 (11) :883-897

[8]

Budde K, 2002, J AM SOC NEPHROL, V13, DOI 10.1681/ASN.V1341073

[9]

Chiba K, 1998, J IMMUNOL, V160, P5037

[10] Suppression of colitis-driven colon cancer in mice by a novel small molecule inhibitor of sphingosine kinase [J].

Chumanevich, Alexander A. ;

Poudyal, Deepak ;

Cui, Xiangli ;

Davis, Tia ;

Wood, Patricia A. ;

Smith, Charles D. ;

Hofseth, Lorne J. .

CARCINOGENESIS, 2010, 31 (10) :1787-1793

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