Self-Emulsifying Drug Delivery Systems (SEDDS): Measuring Energy Dynamics to Determine Thermodynamic and Kinetic Stability

被引：21

作者：

Rehman, Fiza Ur ^{[1
]}

Farid, Arshad ^{[2
]}

Shah, Shefaat Ullah ^{[3
]}

Dar, Muhammad Junaid ^{[1
]}

Rehman, Asim Ur ^{[1
]}

Ahmed, Naveed ^{[1
]}

Rashid, Sheikh Abdur ^{[3
]}

Shaukat, Irfan ^{[4
]}

Shah, Muddaser ^{[5
,6
]}

Albadrani, Ghadeer M. ^{[7
]}

Kamel, Mohamed ^{[8
]}

Altyar, Ahmed E. ^{[9
]}

Abdel-Daim, Mohamed M. ^{[10
,11
]}

Shah, Kifayat Ullah ^{[1
]}

机构：

[1] Quaid I Azam Univ, Fac Biol Sci, Dept Pharm, Islamabad 45320, Pakistan

[2] Gomal Univ, Gomal Ctr Biochem & Biotechnol, Dera Ismail Khan 29050, Pakistan

[3] Gomal Univ, Fac Pharm, GCPS, Skin Regenerat Med & Drug Delivery Res, Dera Ismail Khan 29050, Pakistan

[4] Univ Narowal, Dept Biochem, Narowal 51600, Pakistan

[5] Abdul Wali Khan Univ Mardan, Dept Bot, Mardan 23200, Pakistan

[6] Univ Nizwa, Nat & Med Sci Res Ctr, POB 33, Birkat Al Mauz 616, Nizwa, Oman

[7] Princess Nourah Bint Abdulrahman Univ, Coll Sci, Dept Biol, POB 84428, Riyadh 11671, Saudi Arabia

[8] Cairo Univ, Fac Vet Med, Dept Med & Infect Dis, Giza 12211, Egypt

[9] King Abdulaziz Univ, Fac Pharm, Dept Pharm Practice, Jeddah 21589, Saudi Arabia

[10] Batterjee Med Coll, Dept Pharmaceut Sci, Pharm Program, POB 6231, Jeddah 21442, Saudi Arabia

[11] Suez Canal Univ, Fac Vet Med, Pharmacol Dept, Ismailia 41522, Egypt

来源：

PHARMACEUTICALS | 2022年 / 15卷 / 09期

关键词：

thermodynamic stability; kinetic stability; lipidic formulations; microemulsions; nanoemulsions; self-emulsifying drug delivery system (SEDDS); finasteride; ORAL BIOAVAILABILITY; IN-VITRO; DESIGN; OPTIMIZATION; VIVO; MICROEMULSIONS; NANOEMULSIONS; FINASTERIDE; FORMULATION; SNEDDS;

D O I：

10.3390/ph15091064

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

This research was designed to identify thermodynamically and kinetically stable lipidic self-emulsifying formulations through simple energy dynamics in addition to highlighting and clarifying common ambiguities in the literature in this regard. Proposing a model study, this research shows how most of the professed energetically stable systems are actually energetically unstable, subjected to indiscriminate and false characterization, leading to significant effects for their pharmaceutical applications. A self-emulsifying drug delivery system (SEDDS) was developed and then solidified (S-SEDDS) using a model drug finasteride. Physical nature of SEDDS was identified by measuring simple dynamics which showed that the developed dispersion was thermodynamically unstable. An in vivo study of albino rats showed a three-fold enhanced bioavailability of model drug with SEDDS as compared to the commercial tablets. The study concluded that measuring simple energy dynamics through inherent properties can distinguish between thermodynamically stable and unstable lipidic systems. It might lead to correct identification of a specific lipidic formulation and the application of appropriate characterization techniques accordingly. Future research strategies include improving their pharmaceutical applications and understanding the basic differences in their natures.

引用

页数：21

共 50 条

[1] Self nano-emulsifying simvastatin based tablets: design and in vitro/in vivo evaluation [J].