Hierarchical ultrastructure: An overview of what is known about tendons and future perspective for tendon engineering

被引：40

作者：

Zhang, Shichen ^{[1
,2
,3
]}

Ju, Wei ^{[3
]}

Chen, Xiaoyi ^{[4
]}

Zhao, Yanyan ^{[1
,2
,3
]}

Feng, Lingchong ^{[5
]}

Yin, Zi ^{[3
,6
,7
,8
,9
]}

Chen, Xiao ^{[1
,2
,3
,4
,8
,9
]}

机构：

[1] Zhejiang Univ, Dr Li Dak Sum & Yip Yio Chin Ctr Stem Cell & Rege, Sch Med, Hangzhou 310052, Peoples R China

[2] Zhejiang Univ, Dept Orthoped Surg, Sch Med, Affiliated Hosp 2, Hangzhou 310052, Peoples R China

[3] Zhejiang Univ, Sch Med, Key Lab Tissue Engn & Regenerat Med Zhejiang Prov, Hangzhou 310058, Peoples R China

[4] Guangxi Med Univ, Guangxi ASEAN Collaborat Innovat Ctr Major Dis Pr, Guangxi Key Lab Regenerat Med, Nanning 530021, Guangxi, Peoples R China

[5] Zhejiang Univ, State Key Lab Clean Energy Utilizat, Hangzhou 310058, Zhejiang, Peoples R China

[6] Zhejiang Univ, Dr Li Dak Sum & Yip Yio Chin Ctr Stem Cell & Rege, Sch Med, Hangzhou 310058, Peoples R China

[7] Zhejiang Univ, Dept Orthoped Surg, Sch Med, Sir Run Run Shaw Hosp, Hangzhou 310058, Peoples R China

[8] Zhejiang Univ, Sch Med, Dept Sports Med, Hangzhou 310058, Peoples R China

[9] China Orthoped Regenerat Med Grp CORMed, Hangzhou 310058, Peoples R China

来源：

BIOACTIVE MATERIALS | 2022年 / 8卷

关键词：

Tendon; Collagen fibrillogenesis; Extracellular matrix; FIB-SEM; Biomimetic; OLIGOMERIC MATRIX PROTEIN; HUMAN ACHILLES-TENDON; STEM-CELL DIFFERENTIATION; COLLAGEN FIBRIL STRUCTURE; EXTRACELLULAR-MATRIX; ROTATOR CUFF; I COLLAGEN; MECHANICAL-PROPERTIES; FUNCTIONAL-PROPERTIES; TENASCIN-C;

D O I：

10.1016/j.bioactmat.2021.06.007

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Abnormal tendons are rarely ever repaired to the natural structure and morphology of normal tendons. To better guide the repair and regeneration of injured tendons through a tissue engineering method, it is necessary to have insights into the internal morphology, organization, and composition of natural tendons. This review summarized recent researches on the structure and function of the extracellular matrix (ECM) components of tendons and highlight the application of multiple detection methodologies concerning the structure of ECMs. In addition, we look forward to the future of multi-dimensional biomaterial design methods and the potential of structural repair for tendon ECM components. In addition, focus is placed on the macro to micro detection methods for tendons, and current techniques for evaluating the extracellular matrix of tendons at the micro level are introduced in detail. Finally, emphasis is given to future extracellular matrix detection methods, as well as to how future efforts could concentrate on fabricating the biomimetic tendons.

引用

页码：124 / 139

页数：16

共 174 条

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