Enantioselective syntheses of homophenylalanine derivatives via nitrone 1,3-dipolar cycloaddition reactions with styrenes

被引：35

作者：

Long, A ^{[1
]}

Baldwin, SW ^{[1
]}

机构：

[1] Duke Univ, Dept Chem, Paul M Gross Chem Lab, Durham, NC 27708 USA

来源：

TETRAHEDRON LETTERS | 2001年 / 42卷 / 32期

基金：

美国国家科学基金会;

关键词：

D O I：

10.1016/S0040-4039(01)00821-8

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new two-step route to derivatives of homophenylalanine is presented. Cycloaddition of a cyclic nitrone glycine template with various styrene derivatives affords good yields of 5-substituted cycloadducts. One-step hydrogenolysis (three bonds) then affords the optically pure a-amino acids related to homophenylalanine. (C) 2001 Published by Elsevier Science Ltd.

引用

页码：5343 / 5345

页数：3

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