Biofunctionalization of zinc oxide nanowires for DNA sensory applications

被引：38

作者：

Niepelt, Raphael ^{[1
]}

Schroeder, Ulrich C. ^{[1
]}

Sommerfeld, Jana ^{[1
]}

Slowik, Irma ^{[1
]}

Rudolph, Bettina ^{[2
]}

Moeller, Robert ^{[2
]}

Seise, Barbara ^{[2
]}

Csaki, Andrea ^{[2
]}

Fritzsche, Wolfgang ^{[2
]}

Ronning, Carsten ^{[1
]}

机构：

[1] Univ Jena, Inst Solid State Phys, D-07743 Jena, Germany

[2] Inst Photon Technol IPHT, D-07702 Jena, Germany

来源：

NANOSCALE RESEARCH LETTERS | 2011年 / 6卷

关键词：

nanowires; zinc oxide; functionalization; fluorescence microscopy; sensor technology; ZNO NANOSTRUCTURES; SILICON NANOWIRES; GROWTH; FUNCTIONALIZATION; IMMOBILIZATION; HYBRIDIZATION; MICROARRAYS; STABILITY; NANORODS; BEHAVIOR;

D O I：

10.1186/1556-276X-6-511

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

We report on the biofunctionalization of zinc oxide nanowires for the attachment of DNA target molecules on the nanowire surface. With the organosilane glycidyloxypropyltrimethoxysilane acting as a bifunctional linker, amino-modified capture molecule oligonucleotides have been immobilized on the nanowire surface. The dye-marked DNA molecules were detected via fluorescence microscopy, and our results reveal a successful attachment of DNA capture molecules onto the nanowire surface. The electrical field effect induced by the negatively charged attached DNA molecules should be able to control the electrical properties of the nanowires and gives way to a ZnO nanowire-based biosensing device.

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页码：1 / 7

页数：7

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