Clonal Hematopoiesis: From Mechanisms to Clinical Intervention

被引：42

作者：

Kohnke, Thomas

Majeti, Ravindra ^{[1
]}

机构：

[1] Stanford Univ, Stanford Inst Stem Cell Biol & Regenerat Med, Sch Med, Lokey Stem Cell Bldg,265 Campus Dr, Stanford, CA 94305 USA

来源：

CANCER DISCOVERY | 2021年 / 11卷 / 12期

关键词：

STEM-CELL DONORS; SOMATIC MUTATIONS; TET2; MUTATIONS; MYELOID NEOPLASMS; HEART-FAILURE; SELF-RENEWAL; RISK; LEUKEMIA; AGE; GENE;

D O I：

10.1158/2159-8290.CD-21-0901

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Our knowledge of how clonal hematopoiesis relates to diverse health conditions has grown vastly over the past years, touching upon many specialties beyond cancer medicine. Given that clonal hematopoiesis can act as a precursor to overt disease in many settings, the promise of early intervention has garnered much attention. In this review, we discuss the state of clonal hematopoiesis research and outline the challenges in developing clinical trials of early interventions. We anticipate that incidental findings of clonal hematopoiesis will become more common in the near future, but evidence-based efforts of how to manage these findings is currently lacking. Significance: Our knowledge regarding the relevance of clonal hematopoiesis has increased drastically over the past years. However, evidence of how to manage these findings is currently lacking. In this review, we summarize the current state of clonal hematopoiesis research and outline the challenges of developing clinical trials in this field. We anticipate that incidental findings of clonal hematopoiesis will become more common in the near future and argue that there is urgency to start designing and conducting prospective trials.

引用

页码：2987 / 2997

页数：11

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