Hereditary Susceptibility for Triple Negative Breast Cancer Associated With Western Sub-Saharan African Ancestry Results From an International Surgical Breast Cancer Collaborative

被引：62

作者：

Newman, Lisa A. ^{[1
]}

Jenkins, Brittany ^{[1
]}

Chen, Yalei ^{[2
]}

Oppong, Joseph K. ^{[3
]}

Adjei, Ernest ^{[3
]}

Jibril, Aisha S. ^{[4
]}

Hoda, Syed ^{[1
]}

Cheng, Esther ^{[1
]}

Chitale, Dhananjay ^{[3
]}

Bensenhaver, Jessica M. ^{[3
]}

Awuah, Baffour ^{[3
]}

Bekele, Mahteme ^{[4
]}

Abebe, Engida ^{[4
]}

Kyei, Ishmael ^{[3
]}

Aitpillah, Frances ^{[3
]}

Adinku, Michael ^{[3
]}

Nathanson, Saul David ^{[2
]}

Jackson, LaToya ^{[2
]}

Jiagge, Evelyn ^{[5
]}

Merajver, Sofia ^{[5
]}

Petersen, Lindsay F. ^{[2
]}

Proctor, Erica ^{[2
]}

Gyan, Kofi K. ^{[1
]}

Martini, Rachel ^{[1
]}

Kittles, Rick ^{[6
]}

Davis, Melissa B. ^{[1
]}

机构：

[1] Weill Cornell Med, New York, NY 10065 USA

[2] Henry Ford Canc Inst, Detroit, MI USA

[3] Komfo Anokye Teaching Hosp, Kumasi, Ghana

[4] St Pauls Hosp Millenium Med Coll, Addis Ababa, Ethiopia

[5] Univ Michigan, Ann Arbor, MI 48109 USA

[6] City Hope Natl Med Ctr, Comprehens Canc Ctr, Los Angeles, CA USA

来源：

ANNALS OF SURGERY | 2019年 / 270卷 / 03期

关键词：

African ancestry; disparities; triple negative breast cancer; DUFFY BLOOD-GROUP; CLINICAL ONCOLOGY/COLLEGE; RACIAL DISPARITIES; AMERICAN SOCIETY; WHITE AMERICAN; PREVALENCE; POPULATION; RECEPTOR; SURVIVAL; RECOMMENDATIONS;

D O I：

10.1097/SLA.0000000000003459

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

Objective: To investigate subtype-specific risk of germline alleles associated with triple negative breast cancer (TNBC) in African ancestry populations. Background: Breast cancer (BC) mortality is higher in African American (AA) compared to White American (WA) women; this disparity is partly explained by 2-fold higher TNBC incidence. Methods: We used a surgically maintained biospecimen cohort of 2884 BC cases. Subsets of the total (760 AA; 962 WA; 910 West African/Ghanaian; 252 East African/Ethiopian) were analyzed for genotypes of candidate alleles. A subset of 417 healthy controls were also genotyped, to measure associations with overall BC risk and TNBC. Results: TNBC frequency was highest in Ghanaian and AA cases (49% and 44% respectively; P < 0.0001) and lowest in Ethiopian and WA cases (17% and 24% respectively; P < 0.0001). TNBC cases had higher West African ancestry than non-TNBC (P < 0.0001). Frequency of the Duffy-null allele (rs2814778; an African ancestral variant adopted under selective pressure as protection against malaria) was associated with TNBC-specific risk (P < 0.0001), quantified West African Ancestry (P < 0.0001) and was more common in AA, Ghanaians, and TNBC cases. Additionally, rs4849887 was significantly associated with overall BC risk, and both rs2363956 and rs13000023 were associated with TNBC-specific risk, although none as strongly as the Duffy-null variant. Conclusions: West African ancestry is strongly correlated with TNBC status, as well as germline variants related to BC risk. The Duffy-null allele was associated with TNBC risk in our cohort.

引用

页码：484 / 492

页数：9

共 38 条

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