Construction of homo and heteronuclear Ru(II), Ir(III) and Re(I) complexes for target specific cancer therapy

被引：43

作者：

Pete, Sudhindra ^{[1
]}

Roy, Nilmadhab ^{[1
]}

Kar, Binoy ^{[1
]}

Paira, Priyankar ^{[1
]}

机构：

[1] Vellore Inst Technol, Sch Adv Sci, Dept Chem, Vellore 632014, Tamil Nadu, India

来源：

COORDINATION CHEMISTRY REVIEWS | 2022年 / 460卷

关键词：

Homonuclear; Heteronuclear Ru(II)/Ir(III)/Re(I); Target specificity; Cancer therapy; RUTHENIUM(II) POLYPYRIDYL COMPLEXES; CELL-CYCLE ARREST; CYCLOMETALATED IRIDIUM(III) COMPLEXES; IN-VITRO CYTOTOXICITY; PHOSPHORESCENT RHENIUM(I) COMPLEXES; FLUORESCENT-PROBE LOCALIZATION; APOPTOSIS-INDUCING PROPERTIES; HALF-SANDWICH IRIDIUM(III); ANTICANCER ACTIVITY; DNA-BINDING;

D O I：

10.1016/j.ccr.2022.214462

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

More than 10 million death tolls in 2020 were reported as a result of heinous impact of cancer, making it second most prime cause of death after cardiovascular diseases. In annihilation of cancer, many platinum-based drugs are currently being applied in anticancer therapy but the therapeutic value of these complexes comes with severe side effects. Hence, a profound research is needed to develop more selective and target specific chemotherapeutics so as to diminish the side effects. In this scenario, the anticancer activity of ruthenium, iridium and rhenium-based complexes have shown a light of hope for being explored as anticancer metallotherapeutics. This present review article, therefore, delineates the study of cellular uptake, localisation, mechanism of action and cytotoxicity profiles of several mononuclear and multinuclear ruthenium, iridium and rhenium complexes as target specific potential chemotherapeutic agents. (C) 2022 Elsevier B.V. All rights reserved.

引用

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