Neuropeptide AF is associated with short-term reduced food intake in rats

被引：6

作者：

Newmyer, Brandon A. ^{[1
]}

Cline, Mark A. ^{[1
]}

机构：

[1] Radford Univ, Dept Biol, Radford, VA 24142 USA

来源：

BEHAVIOURAL BRAIN RESEARCH | 2011年 / 219卷 / 02期

关键词：

Rat; Food intake; Neuropeptide AF; NPAF; FF; BEHAVIOR; MORPHINE; FMRFAMIDE; PEPTIDES;

D O I：

10.1016/j.bbr.2010.12.001

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

Neuropeptide AF (NPAF), a member of the RFamide family, was centrally administered to rats to determine its effect on food intake. Rats responded with a linear dose-dependent reduction in cumulative food intake up to 3 h post injection, but when analyzed on a noncumulative basis, food intake was only significantly reduced at 0.5 h. To our knowledge, this is the first report of NPAF-induced reduction in food intake in a mammalian model. (C) 2010 Elsevier B.V. All rights reserved.

引用

收藏

页码：351 / 353

页数：3

相关论文

共 20 条

[1] CORTICOSTERONE MODULATION OF DIETARY SELECTION PATTERNS [J].

BLIGH, ME ;

DOUGLASS, LW ;

CASTONGUAY, TW .

PHYSIOLOGY & BEHAVIOR, 1993, 53 (05) :975-982

[2] Identification and characterization of two G protein-coupled receptors for neuropeptide FF [J].

Bonini, JA ;

Jones, LK ;

Adham, N ;

Forray, C ;

Artymyshyn, R ;

Durkin, MM ;

Smith, KE ;

Tamm, JA ;

Boteju, LW ;

Lakhlani, PP ;

Raddatz, R ;

Yao, WJ ;

Ogozalek, KL ;

Boyle, N ;

Kouranova, EV ;

Quan, Y ;

Vaysse, PJ ;

Wetzel, JM ;

Branchek, TA ;

Gerald, C ;

Borowsky, B .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (50) :39324-39331

[3] The Anorectic Effect of Neuropeptide AF is Associated with Satiety-Related Hypothalamic Nuclei [J].

Cline, M. A. ;

Newmyer, B. A. ;

Smith, M. L. .

JOURNAL OF NEUROENDOCRINOLOGY, 2009, 21 (07) :595-601

[4] Natural variation in a neuropeptide Y receptor homolog modifies social behavior and food response in C-elegans [J].

de Bono, M ;

Bargmann, CI .

CELL, 1998, 94 (05) :679-689

[5] In vitro analysis of the digestive enzymes amylase and α-glucosidase in the midguts of Locusta migratoria L. in response to the myosuppressin, SchistoFLRFamide [J].

Hill, SR ;

Orchard, I .

JOURNAL OF INSECT PHYSIOLOGY, 2005, 51 (01) :1-9

[6] EFFECT OF ACTH ON WEIGHT-GAIN, FOOD-INTAKE AND PLASMA-GLUCOSE CONCENTRATIONS IN SPRAGUE-DAWLEY RATS [J].

KAMARA, AK ;

KAMARA, KS ;

CASTONGUAY, TW .

APPETITE, 1992, 19 (02) :191-191

[7] INHIBITORY INFLUENCES OF MAMMALIAN FMRFAMIDE (PHE-MET-ARG-PHE-AMIDE)-RELATED PEPTIDES ON NOCICEPTION AND MORPHINE-INDUCED AND STRESS-INDUCED ANALGESIA IN MICE [J].

KAVALIERS, M .

NEUROSCIENCE LETTERS, 1990, 115 (2-3) :307-312

[8] Central circuitry in the jellyfish Aglantha digitale -: IV.: Pathways coordinating feeding behaviour [J].

Mackie, GO ;

Marx, RM ;

Meech, RW .

JOURNAL OF EXPERIMENTAL BIOLOGY, 2003, 206 (14) :2487-2505

[9] Endocrine, behavioral and autonomic effects of neuropeptide AF [J].

Miklos Jaszberenyi ;

Zsolt Bagosi ;

Balazs Thurzo ;

Imre Foeldesi ;

Gyula Szabo ;

Gyula Telegdy .

HORMONES AND BEHAVIOR, 2009, 56 (01) :24-34

[10] Neuropeptide FF reduces food intake in rats [J].

Murase, T ;

Arima, H ;

Kondo, K ;

Oiso, Y .

PEPTIDES, 1996, 17 (02) :353-354