Grabbing your ear: Rapid auditory-somatosensory multisensory interactions in low-level sensory cortices are not constrained by stimulus alignment

被引:311
作者
Murray, MM
Molholm, S
Michel, CM
Heslenfeld, DJ
Ritter, W
Javitt, DC
Schroeder, CE
Foxe, JJ
机构
[1] Nathan S Kline Inst Psychiat Res, Cognit Neurosci Lab, Program Cognit Neurosci & Schizophrenia, Orangeburg, NY 10962 USA
[2] CHU Vaudois, Div Autonome Neuropsychol, Lausanne, Switzerland
[3] CHU Vaudois, Serv Radiodiagnost & Radiol Interventionnelle, Lausanne, Switzerland
[4] Univ Hosp Geneva, Dept Neurol, Geneva, Switzerland
[5] Free Univ Amsterdam, Dept Cognit Psychol, Amsterdam, Netherlands
[6] Albert Einstein Coll Med, Dept Neurosci, New York, NY USA
关键词
area CM; cross-modal; event-related potential (ERP); human; LAURA source estimation; redundant signals effect (RSE);
D O I
10.1093/cercor/bhh197
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Multisensory interactions are observed in species from single-cell organisms to humans. Important early work was primarily carried out in the cat superior colliculus and a set of critical parameters for their occurrence were defined. Primary among these were temporal synchrony and spatial alignment of bisensory inputs. Here, we assessed whether spatial alignment was also a critical parameter for the temporally earliest multisensory interactions that are observed in lower-level sensory cortices of the human. While multisensory interactions in humans have been shown behaviorally for spatially disparate stimuli ( e. g. the ventriloquist effect), it is not clear if such effects are due to early sensory level integration or later perceptual level processing. In the present study, we used psychophysical and electrophysiological indices to show that auditory-somatosensory interactions in humans occur via the same early sensory mechanism both when stimuli are in and out of spatial register. Subjects more rapidly detected multisensory than unisensory events. At just 50 ms post-stimulus, neural responses to the multisensory 'whole' were greater than the summed responses from the constituent unisensory 'parts'. For all spatial configurations, this effect followed from a modulation of the strength of brain responses, rather than the activation of regions specifically responsive to multisensory pairs. Using the local auto-regressive average source estimation, we localized the initial auditory-somatosensory interactions to auditory association areas contralateral to the side of somatosensory stimulation. Thus, multisensory interactions can occur across wide peripersonal spatial separations remarkably early in sensory processing and in cortical regions traditionally considered unisensory.
引用
收藏
页码:963 / 974
页数:12
相关论文
共 90 条
  • [1] ENCODING OF SOUND-SOURCE LOCATION AND MOVEMENT - ACTIVITY OF SINGLE NEURONS AND INTERACTIONS BETWEEN ADJACENT NEURONS IN THE MONKEY AUDITORY-CORTEX
    AHISSAR, M
    AHISSAR, E
    BERGMAN, H
    VAADIA, E
    [J]. JOURNAL OF NEUROPHYSIOLOGY, 1992, 67 (01) : 203 - 215
  • [2] Intentional maps in posterior parietal cortex
    Andersen, RA
    Buneo, CA
    [J]. ANNUAL REVIEW OF NEUROSCIENCE, 2002, 25 : 189 - 220
  • [3] [Anonymous], 1987, METHODS ANAL BRAIN E
  • [4] Bertelson P., 1988, ADV PSYCHOL SCI, V2, P419
  • [5] Brungart DS, 2003, AVIAT SPACE ENVIR MD, V74, P937
  • [6] Tactile "capture" of audition
    Caclin, A
    Soto-Faraco, S
    Kingstone, A
    Spence, C
    [J]. PERCEPTION & PSYCHOPHYSICS, 2002, 64 (04): : 616 - 630
  • [7] Crossmodal processing in the human brain: Insights from functional neuroimaging studies
    Calvert, GA
    [J]. CEREBRAL CORTEX, 2001, 11 (12) : 1110 - 1123
  • [8] What and Where in human audition: selective deficits following focal hemispheric lesions
    Clarke, S
    Thiran, AB
    Maeder, P
    Adriani, M
    Vernet, O
    Regli, L
    Cuisenaire, O
    Thiran, JP
    [J]. EXPERIMENTAL BRAIN RESEARCH, 2002, 147 (01) : 8 - 15
  • [9] Complex movements evoked by microstimulation of the ventral intraparietal area
    Cooke, DF
    Taylor, CSR
    Moore, T
    Graziano, MSA
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (10) : 6163 - 6168
  • [10] DEPERALTA RG, 2001, BRAIN TOPOGR, V14, P131