Autophagy Stimulation Abrogates Herpes simplex Virus-1 Infection

被引：52

作者：

Yakoub, Abraam M. ^{[1
,2
]}

Shukla, Deepak ^{[1
,2
]}

机构：

[1] Univ Illinois, Dept Microbiol & Immunol, Chicago, IL 60612 USA

[2] Univ Illinois, Med Ctr, Dept Ophthalmol & Visual Sci, Chicago, IL 60612 USA

来源：

SCIENTIFIC REPORTS | 2015年 / 5卷

关键词：

ANTIVIRAL DEFENSE; SURVIVAL;

D O I：

10.1038/srep09730

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Herpes simplex virus-1 (HSV-1) is a double-stranded DNA virus that causes life-long infections. HSV-1 infections may lead to herpetic stromal keratitis that may advance to corneal blindness. HSV-1 infections can also cause fatal conditions, such as herpes encephalitis, or neonatal disease. A major virulence mechanism of HSV-1 is the control of autophagy, an innate immune defense strategy that could otherwise degrade viral particles. Here, to investigate a new mechanism for antiviral therapy, we tested the effect of various autophagy inducers (physiological and pharmacological) on infection. Autophagy stimulation was confirmed to significantly suppress HSV-1 infection in various cell types, without affecting cell viability. This study establishes the importance of autophagy for regulating HSV-1 infection, and provides a proof-of-principle evidence for a novel antiviral mechanism.

引用

页数：7

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