A novel thioredoxin reductase inhibitor inhibits cell growth and induces apoptosis in HL-60 and K562 cells

被引：14

作者：

Peng, Zuo-fu ^{[1
]}

Lan, Lin-xiang ^{[1
]}

Zhao, Fang ^{[1
]}

Li, Jing ^{[1
]}

Tan, Qiang ^{[2
]}

Yin, Han-wei ^{[3
]}

Zeng, Hui-hui ^{[1
]}

机构：

[1] Peking Univ, Sch Pharmaceut Sci, Dept Biol Chem, Beijing 100083, Peoples R China

[2] Peking Univ First Hosp, Dept Geriatr Med, Beijing 100034, Peoples R China

[3] Peking Univ, Coll Life Sci, Beijing 100075, Peoples R China

来源：

JOURNAL OF ZHEJIANG UNIVERSITY-SCIENCE B | 2008年 / 9卷 / 01期

基金：

中国国家自然科学基金;

关键词：

thioredoxin reductase (TrxR); novel TrxR inhibitor; 1,2-[bis(1,2-benzisoselenazolone-3(2H)-ketone)]ethane (BBSKE); apoptosis;

D O I：

10.1631/jzus.B071605

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Human thioredoxin reductase (TrxR) system is associated with cancer cell growth and anti-apoptosis process. Effects of 1,2-[bis(1,2-benzisoselenazolone-3(2H)-ketone)]ethane (BBSKE), a novel TrxR inhibitor, were investigated on human leukemia cell lines HL-60 and K562. BBSKE treatment induced cell growth inhibition and apoptosis in both cell lines. Apoptosis induced by BBSKE is through Bcl-2/Bax and caspase-3 pathways. Ehrlich's ascites carcinoma-bearing mice were used to investigate the anti-tumor effect of BBSKE in vivo. Tumor-bearing mice treated with BBSKE showed an increase of life span with a comparable effect to cyclophosphamide (CTX). These results suggest a potential usage of BBSKE as a therapeutic agent against non-solid tumors.

引用

页码：16 / 21

页数：6

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