Proton MR spectroscopic imaging of the medulla and cervical spinal cord

被引:18
作者
Edden, Richard A. E.
Bonekamp, David
Smith, Mari A.
Dubey, Prachi
Barker, Peter B.
机构
[1] Johns Hopkins Univ, Sch Med, Russell H Morgan Dept Radiol & Radiol Sci, Baltimore, MD USA
[2] Kennedy Krieger Inst, FM Kirby Res Ctr Funct Brain Imaging, Baltimore, MD USA
[3] Mem Sloan Kettering Canc Ctr, Dept Med Phys, New York, NY 10021 USA
关键词
magnetic resonance spectroscopic imaging; medulla; spinal cord; 3; Tesla; metabolism;
D O I
10.1002/jmri.21008
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
Purpose: To demonstrate the feasibility of quantitative, one-dimensional proton MR spectroscopic imaging (1D-MRSI) of the upper cervical. spine and medulla at 3.0 Tesla. Materials and Methods: A method was developed for ID-point-resolved spectroscopy sequence (PRESS)-MRSI, exciting signal in five voxels extending from the pontomedullary junction to the level of the C3 vertebra, and performed in 10 healthy volunteers to generate control data. Results: High-resolution 1D-MRSI data were obtained from all 10 subjects. Upper cervical spine concentrations of choline, creatine, and N-acetyl aspartate were estimated to be 2.8 +/- 0.5, 8.8 +/- 1.8, and 10.9 +/- 2.7 mM, respectively, while in the medulla they were 2.6 +/- 0.5, 9.1 +/- 1.7, and 10.8 +/- 0.9 mM. Conclusion: Quantitative 1D-MRSI of the upper cervical spine has been shown to be feasible at 3.0 Tesla.
引用
收藏
页码:1101 / 1105
页数:5
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