Assessment and prediction of tablet properties using transmission and backscattering Raman spectroscopy and transmission NIR spectroscopy

被引：30

作者：

Peeters, Elisabeth ^{[1
]}

Tavares da Silva, Ana Filipa ^{[2
,3
]}

Toiviainen, Maunu ^{[4
]}

Van Renterghem, Jeroen ^{[2
]}

Vercruysse, Jurgen ^{[1
]}

Juuti, Mikko ^{[4
]}

Lopes, Joao Almeida ^{[3
]}

De Beer, Thomas ^{[2
]}

Vervaet, Chris ^{[1
]}

Remon, Jean-Paul ^{[1
]}

机构：

[1] Univ Ghent, Lab Pharmaceut Technol, Ottergemsesteenweg 460, B-9000 Ghent, Belgium

[2] Univ Ghent, Lab Pharmaceut Proc Analyt Technol, Ottergemsesteenweg 460, B-9000 Ghent, Belgium

[3] Univ Porto, Dept Chem Sci, REQUIMTE, Rua Jorge Viterbo Ferreira 228, P-4050313 Oporto, Portugal

[4] VTT Tech Res Ctr Finland, Opt Measurement Technol, Kaitovayla 1, Oulu 90570, Finland

来源：

ASIAN JOURNAL OF PHARMACEUTICAL SCIENCES | 2016年 / 11卷 / 04期

关键词：

Continuous production; PAT; Granulation; Tableting; NIR; Raman; NEAR-INFRARED SPECTROSCOPY; TWIN-SCREW GRANULATION; DIFFUSE-REFLECTANCE SPECTROSCOPY; WET GRANULATION; NONDESTRUCTIVE METHOD; DRUG CONTENT; HARDNESS; GRANULES; SCATTERING; REDUCTION;

D O I：

10.1016/j.ajps.2016.04.004

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

This study investigated whether Raman and Near Infrared (NIR) spectroscopy could predict tablet properties. Granules were produced on a continuous line by varying granulation parameters. Tableting process parameters were adjusted to obtain uniform tablet weight and thickness. Spectra were collected offline and tablet properties determined with traditional analyzing methods. Partial Least Squares (PLS) regression was used to correlate spectral information to tablet properties, but predictive models couldn't be established. Principal component analysis (PCA) was effectively used to distinguish theophylline concentrations and hydration levels and multiple linear regression (MLR) analysis allowed insight on how granulation parameters affect granule and tablet properties. (C) 2016 Shenyang Pharmaceutical University. Production and hosting by Elsevier B.V. This is an open access article under the CC BY-NC-ND license

引用

页码：547 / 558

页数：12

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