Regulatory T cells in oral squamous cell carcinoma

被引：31
作者：
Liu, Sai [1 ]
Liu, Dongjuan [1 ]
Li, Jing [1 ]
Zhang, Dunfang [1 ]
Chen, Qianming [1 ]
机构：
[1] Sichuan Univ, State Key Lab Oral Dis, West China Coll Stomatol, 14,Sec 3 Renminnan Rd, Chengdu 610041, Sichuan, Peoples R China
来源：
JOURNAL OF ORAL PATHOLOGY & MEDICINE | 2016年 / 45卷 / 09期
基金：
中国国家自然科学基金;
关键词：
FOXP3; oral squamous cell carcinoma; Tregs; tumor immunotherapy; TUMOR-INFILTRATING LYMPHOCYTES; PROGNOSTIC VALUE; IMMUNE DYSREGULATION; PERIPHERAL-BLOOD; SUPPRESSOR-CELLS; CANCER; HEAD; EXPRESSION; POLYENDOCRINOPATHY; SUBPOPULATIONS;
D O I：
10.1111/jop.12445
中图分类号：
R78 [口腔科学];
学科分类号：
1003 ;
摘要：
Regulatory T cells (Tregs) play a critical role in modulating and maintaining immune homeostasis and tolerance. They accumulate in many types of tumors and play a critical role in tumor evasion of immune surveillance. Oral cancer is characterized by an increase in the number of infiltrating Tregs; however, the significance of this increase on the prognosis of oral cancer is controversial. This review focuses on the function of Tregs in oral squamous cell carcinoma and its implications on prognosis. We also discuss potential therapeutic strategies aimed at Tregs modification in oral SCC.
引用
收藏
页码：635 / 639
页数：5
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