Regulation of fetal male germ cell development by members of the TGFβ superfamily

被引：18
|
作者：
Spiller, Cassy [1 ]
Burnet, Guillaume [1 ]
Bowles, Josephine [1 ,2 ]
机构：
[1] Univ Queensland, Sch Biomed Sci, Brisbane, Qld 4072, Australia
[2] Univ Queensland, Inst Mol Biosci, Brisbane, Qld 4072, Australia
来源：
STEM CELL RESEARCH | 2017年 / 24卷
基金：
英国医学研究理事会;
关键词：
Germ cells; TGF beta; Activins; Nodal; Cripto; EMBRYONIC STEM-CELLS; RETINOIC ACID; ACTIVIN-A; SUPPRESSES MEIOSIS; TESTIS DEVELOPMENT; MOUSE TESTIS; MICE; CRIPTO; SEX; DIFFERENTIATION;
D O I：
10.1016/j.scr.2017.07.016
中图分类号：
Q813 [细胞工程];
学科分类号：
摘要：
There is now substantial evidence that members of the transforming growth factor-beta (TGF beta family) regulate germ cell development in the mouse fetal testis. Correct development of germ cells during fetal life is critical for establishment of effective spermatogenesis and for avoiding the formation of testicular germ cell cancer in later life. Here we consider the evidence for involvement of various TGF beta family members, attempt to reconcile discrepancies and clarify what we believe to be the likely in vivo roles of these factors. Crown Copyright (C) 2017 Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license.
引用
收藏
页码：174 / 180
页数：7
相关论文
共 50 条
  • [41] Somatic regulation of female germ cell regeneration and development in planarians
    Khan, Umair W.
    Newmark, Phillip A.
    CELL REPORTS, 2022, 38 (11):
  • [42] TGF-β superfamily members do not promote smooth muscle-specific alternative splicing, a late marker of vascular smooth muscle cell differentiation
    King-Briggs, KE
    Shanahan, CM
    DIFFERENTIATION, 2000, 66 (01) : 43 - 48
  • [43] The proto-oncogene Ret is required for male foetal germ cell survival
    Miles, Denise C.
    van den Bergen, Jocelyn A.
    Wakeling, Stephanie I.
    Anderson, Richard B.
    Sinclair, Andrew H.
    Western, Patrick S.
    DEVELOPMENTAL BIOLOGY, 2012, 365 (01) : 101 - 109
  • [44] Advanced immunostaining approaches to study early male germ cell development
    Niedenberger, Bryan A.
    Geyer, Christopher B.
    STEM CELL RESEARCH, 2018, 27 : 162 - 168
  • [45] Regulation of Translocator Protein 18 kDa (TSPO) Expression in Rat and Human Male Germ Cells
    Manku, Gurpreet
    Culty, Martine
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2016, 17 (09):
  • [46] Sex-specific differences in fetal germ cell apoptosis induced by ionizing radiation
    Guerquin, Marie-Justine
    Duquenne, Clotilde
    Coffigny, Herve
    Rouiller-Fabre, Virginie
    Lambrot, Romain
    Bakalska, Mariana
    Frydman, Rene
    Habert, Rene
    Livera, Gabriel
    HUMAN REPRODUCTION, 2009, 24 (03) : 670 - 678
  • [47] Synergistic effect of TGF-β superfamily members on the induction of Foxp3+ Treg
    Lu, Ling
    Ma, Jilin
    Wang, Xuehao
    Wang, Julie
    Zhang, Feng
    Yu, Jiangning
    He, Ge
    Xu, Bing
    Brand, David D.
    Horwitz, David A.
    Shi, Wei
    Zheng, Song Guo
    EUROPEAN JOURNAL OF IMMUNOLOGY, 2010, 40 (01) : 142 - 152
  • [48] Negative regulation of TGF-β signaling in development
    Chen, YG
    Meng, AM
    CELL RESEARCH, 2004, 14 (06) : 441 - 449
  • [49] Regulation of homeostasis and regeneration in the adult intestinal epithelium by the TGF-β superfamily
    Fink, Mardi
    Wrana, Jeffrey L.
    DEVELOPMENTAL DYNAMICS, 2023, 252 (04) : 445 - 462
  • [50] TGF-β superfamily: how does it regulate testis development
    Yun-Shu Fan
    Yan-Jun Hu
    Wan-Xi Yang
    Molecular Biology Reports, 2012, 39 : 4727 - 4741
12345