Regulation of fetal male germ cell development by members of the TGFβ superfamily

被引：18
|
作者：
Spiller, Cassy [1 ]
Burnet, Guillaume [1 ]
Bowles, Josephine [1 ,2 ]
机构：
[1] Univ Queensland, Sch Biomed Sci, Brisbane, Qld 4072, Australia
[2] Univ Queensland, Inst Mol Biosci, Brisbane, Qld 4072, Australia
来源：
STEM CELL RESEARCH | 2017年 / 24卷
基金：
英国医学研究理事会;
关键词：
Germ cells; TGF beta; Activins; Nodal; Cripto; EMBRYONIC STEM-CELLS; RETINOIC ACID; ACTIVIN-A; SUPPRESSES MEIOSIS; TESTIS DEVELOPMENT; MOUSE TESTIS; MICE; CRIPTO; SEX; DIFFERENTIATION;
D O I：
10.1016/j.scr.2017.07.016
中图分类号：
Q813 [细胞工程];
学科分类号：
摘要：
There is now substantial evidence that members of the transforming growth factor-beta (TGF beta family) regulate germ cell development in the mouse fetal testis. Correct development of germ cells during fetal life is critical for establishment of effective spermatogenesis and for avoiding the formation of testicular germ cell cancer in later life. Here we consider the evidence for involvement of various TGF beta family members, attempt to reconcile discrepancies and clarify what we believe to be the likely in vivo roles of these factors. Crown Copyright (C) 2017 Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license.
引用
收藏
页码：174 / 180
页数：7
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