Efficient lactobionic acid production from whey by Pseudomonas taetrolens under pH-shift conditions

被引：65

作者：

Alonso, Saul ^{[1
]}

Rendueles, Manuel ^{[1
]}

Diaz, Mario ^{[1
]}

机构：

[1] Univ Oviedo, Fac Chem, Dept Chem Engn & Environm Technol, E-33071 Oviedo, Spain

来源：

BIORESOURCE TECHNOLOGY | 2011年 / 102卷 / 20期

关键词：

Whey; Lactobionic acid; Pseudomonas taetrolens; Biotechnological upgrading; Oxidative bioconversion; LACTOSE DERIVATIVES; OXIDATION; SORBITOL; CHITOSAN; FRUCTOSE;

D O I：

10.1016/j.biortech.2011.07.089

中图分类号：

S2 [农业工程];

学科分类号：

0828 ;

摘要：

Lactobionic acid finds applications in the fields of pharmaceuticals, cosmetics and medicine. The production of lactobionic acid from whey by Pseudomonas taetrolens was studied in shake-flasks and in a bioreactor. Shake-flask experiments showed that lactobionic acid was a non-growth associated product. A two-stage pH-shift bioconversion strategy with a pH-uncontrolled above 6.5 during the growth phase and maintained at 6.5 during cumulative production was adopted in bioreactor batch cultures. An inoculation level of 30% promoted high cell culture densities that triggered lactobionic acid production at a rate of 1.12 g/L h. This methodology displayed efficient bioconversion with cheese whey as an inexpensive substrate for lactobionic acid production. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：9730 / 9736

页数：7

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