Efficient lactobionic acid production from whey by Pseudomonas taetrolens under pH-shift conditions

被引：65

作者：

Alonso, Saul ^{[1
]}

Rendueles, Manuel ^{[1
]}

Diaz, Mario ^{[1
]}

机构：

[1] Univ Oviedo, Fac Chem, Dept Chem Engn & Environm Technol, E-33071 Oviedo, Spain

来源：

BIORESOURCE TECHNOLOGY | 2011年 / 102卷 / 20期

关键词：

Whey; Lactobionic acid; Pseudomonas taetrolens; Biotechnological upgrading; Oxidative bioconversion; LACTOSE DERIVATIVES; OXIDATION; SORBITOL; CHITOSAN; FRUCTOSE;

D O I：

10.1016/j.biortech.2011.07.089

中图分类号：

S2 [农业工程];

学科分类号：

0828 ;

摘要：

Lactobionic acid finds applications in the fields of pharmaceuticals, cosmetics and medicine. The production of lactobionic acid from whey by Pseudomonas taetrolens was studied in shake-flasks and in a bioreactor. Shake-flask experiments showed that lactobionic acid was a non-growth associated product. A two-stage pH-shift bioconversion strategy with a pH-uncontrolled above 6.5 during the growth phase and maintained at 6.5 during cumulative production was adopted in bioreactor batch cultures. An inoculation level of 30% promoted high cell culture densities that triggered lactobionic acid production at a rate of 1.12 g/L h. This methodology displayed efficient bioconversion with cheese whey as an inexpensive substrate for lactobionic acid production. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：9730 / 9736

页数：7

共 32 条

[1]

Affertsholt-Allen T., 2007, P INT DAIR FED S LAC

[2] Catalytic wet oxidation of lactose [J].

Chia, Yah Nan ;

Latusek, Michael P. ;

Holles, Joseph H. .

INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH, 2008, 47 (12) :4049-4055

[3] Preparation of alginate/galactosylated chitosan scaffold for hepatocyte attachment [J].

Chung, TW ;

Yang, J ;

Akaike, T ;

Cho, KY ;

Nah, JW ;

Kim, SI ;

Cho, CS .

BIOMATERIALS, 2002, 23 (14) :2827-2834

[4]

D'Alessandro AM, 1999, TRANSPLANT REV, V13, P67

[5] Lactose:: Crystallization, hydrolysis and value-added derivatives [J].

Gaenzle, Michael G. ;

Haase, Gottfried ;

Jelen, Paul .

INTERNATIONAL DAIRY JOURNAL, 2008, 18 (07) :685-694

[6]

Gerling K. G., 1998, Whey: proceedings of the second international whey conference, held in Chicago, USA, 27-29 October 1997., P251

[7] Clinical and cosmeceutical uses of hydroxyacids [J].

Green, Barbara A. ;

Yu, Ruey J. ;

Van Scott, Eugene J. .

CLINICS IN DERMATOLOGY, 2009, 27 (05) :495-501

[8] Fermentation of lactose to bio-ethanol by yeasts as part of integrated solutions for the valorisation of cheese whey [J].

Guimaraes, Pedro M. R. ;

Teixeira, Jose A. ;

Domingues, Lucilia .

BIOTECHNOLOGY ADVANCES, 2010, 28 (03) :375-384

[9] Synthesis and characterization of biocompatible magnetic glyconanoparticles [J].

Kekkonen, Viktoria ;

Lafreniere, Nelson ;

Ebara, Mitsuhiro ;

Saito, Atsuhiro ;

Sawa, Yoshiki ;

Narain, Ravin .

JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS, 2009, 321 (10) :1393-1396

[10] Polyhydroxyalkanoate production from whey by Pseudomonas hydrogenovora [J].

Koller, Martin ;

Bona, Rodolfo ;

Chiellini, Emo ;

Fernandes, Elizabeth Grillo ;

Horvat, Predrag ;

Kutschera, Christoph ;

Hesse, Paula ;

Braunegg, Gerhart .

BIORESOURCE TECHNOLOGY, 2008, 99 (11) :4854-4863

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