Multivalent peptide and protein dendrimers using native chemical ligation

被引：75
|
作者：
van Baal, I
Malda, H
Synowsky, SA
van Dongen, JLJ
Hackeng, TM
Merkx, M
Meijer, EW
机构：
[1] Eindhoven Univ Technol, Lab Macromol & Organ Chem, NL-5600 MB Eindhoven, Netherlands
[2] Univ Utrecht, Utrecht Inst Pharmaceut Sci, NL-3584 CA Utrecht, Netherlands
[3] Univ Utrecht, Dept Biomol Mass Spectrometry, Bijvoet Ctr Biomol Res, NL-3584 CA Utrecht, Netherlands
[4] Univ Maastricht, Dept Biochem, Cardiovasc Res Inst Maastricht, NL-6200 MD Maastricht, Netherlands
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2005年 / 44卷 / 32期
关键词：
bioorganic chemistry; dendrimers; multivalency; peptides; proteins;
D O I：
10.1002/anie.200500635
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A wide variety of well-defined multivalent peptides and proteins can be made by conjugating synthetic peptides and recombinantly expressed proteins to cysteine-functionalized dendrimers using native chemical ligation (see picture). This modular approach provides access to dendrimers that are attractive both for understanding fundamental issues of multivalency in biological interactions as well as for biomedical applications. (Chemical Equation Presented) © 2005 Wiley-VCH Verlag GmbH & Co. KGaA.
引用
收藏
页码：5052 / 5057
页数：6
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