Cholesterol-Based Compounds: Recent Advances in Synthesis and Applications

被引：58
作者：
Albuquerque, Helio M. T. [1 ,2 ]
Santos, Clementina M. M. [1 ,2 ,3 ]
Silva, Artur M. S. [1 ,2 ]
机构：
[1] Univ Aveiro, Dept Chem, QOPNA, Campus Santiago, P-3810193 Aveiro, Portugal
[2] Univ Aveiro, Dept Chem, LAQV, REQUIMTE, Campus Santiago, P-3810193 Aveiro, Portugal
[3] Inst Politecn Braganca, Ctr Invest Montanha CIMO, Campus Santa Apolonia, P-5300253 Braganca, Portugal
来源：
MOLECULES | 2019年 / 24卷 / 01期
关键词：
cholesterol; drug delivery; bioactive compounds; liquid crystals; gelators; bioimaging; synthesis; POT MULTICOMPONENT SYNTHESIS; PERYLENE LIQUID-CRYSTALS; PHOTOPHYSICAL PROPERTIES; DRUG-DELIVERY; IN-VIVO; ELECTROCHEMICAL SYNTHESIS; SUPRAMOLECULAR GELATOR; BIOLOGICAL EVALUATION; MOLECULAR DOCKING; TARGETED DELIVERY;
D O I：
10.3390/molecules24010116
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
This review reports on the latest developments (since 2014) in the chemistry of cholesterol and its applications in different research fields. These applications range from drug delivery or bioimaging applications to cholesterol-based liquid crystals and gelators. A brief overview of the most recent synthetic procedures to obtain new cholesterol derivatives is also provided, as well as the latest anticancer, antimicrobial, and antioxidant new cholesterol-based derivatives. This review discusses not only the synthetic details of the preparation of new cholesterol derivatives or conjugates, but also gives a short summary concerning the specific application of such compounds.
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页数：68
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