Porphyrin photosensitizers in photodynamic therapy and its applications

被引：446

作者：

Kou, Jiayuan ^{[1
,2
]}

Dou, Dou ^{[3
]}

Yang, Liming ^{[1
]}

机构：

[1] Harbin Med Univ, Dept Pathophysiol, Harbin, Heilongjiang, Peoples R China

[2] Harbin Med Univ, Dept Biochem & Mol Biol, Harbin, Heilongjiang, Peoples R China

[3] Peking Univ, Sch Basic Med Sci, Dept Physiol & Pathophysiol, Hlth Sci Ctr, Beijing, Peoples R China

来源：

ONCOTARGET | 2017年 / 8卷 / 46期

基金：

中国国家自然科学基金;

关键词：

porphyrin photosensitizers; photodynamic therapy; tumor; application; CELL-DEATH; MOTEXAFIN LUTETIUM; HUMAN HEAD; CANCER; APOPTOSIS; PHOTOFRIN; MECHANISMS; FLUORESCENCE; ACTIVATION; RECEPTOR;

D O I：

10.18632/oncotarget.20189

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

In 1841, the extraction of hematoporphyrin from dried blood by removing iron marked the birth of the photosensitizer. The last twenty years has witnessed extensive research in the application of photodynamic therapy (PDT) in tumor-bearing (or other diseases) animal models and patients. The period has seen development of photosensitizers from the first to the third generation, and their evolution from simple to more complex entities. This review focuses on porphyrin photosensitizers and their effect on tumors, mediated via several pathways involved in cell necrosis, apoptosis or autophagic cell death, and the preventive and therapeutic application of PDT against atherosclerosis.

引用

页码：81591 / 81603

页数：13

共 113 条

[1]

AGARWAL ML, 1991, CANCER RES, V51, P5993

[2] Photodynamic Therapy of Cancer: An Update [J].

Agostinis, Patrizia ;

Berg, Kristian ;

Cengel, Keith A. ;

Foster, Thomas H. ;

Girotti, Albert W. ;

Gollnick, Sandra O. ;

Hahn, Stephen M. ;

Hamblin, Michael R. ;

Juzeniene, Asta ;

Kessel, David ;

Korbelik, Mladen ;

Moan, Johan ;

Mroz, Pawel ;

Nowis, Dominika ;

Piette, Jacques ;

Wilson, Brian C. ;

Golab, Jakub .

CA-A CANCER JOURNAL FOR CLINICIANS, 2011, 61 (04) :250-281

[3] Cisplatin enhances the efficacy of 5-aminolevulinic acid-mediated photodynamic therapy in human head and neck squamous cell carcinoma [J].

Ahn, Jin-Chul ;

Biswas, Raktim ;

Mondal, Arindam ;

Lee, Young-Ki ;

Chung, Phil-Sang .

GENERAL PHYSIOLOGY AND BIOPHYSICS, 2014, 33 (01) :53-62

[4] The apoptosis pathway of photodynamic therapy using 9-HpbD-a in AMC-HN3 human head and neck cancer cell line and in vivo [J].

Ahn, Jin-Chul .

GENERAL PHYSIOLOGY AND BIOPHYSICS, 2013, 32 (03) :405-413

[5] Oncologic photodynamic therapy photosensitizers: A clinical review [J].

Allison, Ron R. ;

Sibata, Claudio H. .

PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY, 2010, 7 (02) :61-75

[6] Intracellular signaling mechanisms in photodynamic therapy [J].

Almeida, RD ;

Manadas, BJ ;

Carvalho, AP ;

Duarte, CB .

BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER, 2004, 1704 (02) :59-86

[7] Photodynamic therapy of atherosclerosis using YAG-OPO laser and porfimer sodium, and comparison with using argon-dye laser [J].

Amemiya, T ;

Nakajima, H ;

Katoh, T ;

Rakue, H ;

Miyagi, M ;

Ibukiyama, C .

JAPANESE CIRCULATION JOURNAL-ENGLISH EDITION, 1999, 63 (04) :288-295

[8] Gene transfer-mediated intracellular photodynamic therapy [J].

Babincová, M ;

Sourivong, P ;

Babinec, P .

MEDICAL HYPOTHESES, 2000, 54 (02) :180-181

[9] Porphyrin-related photosensitizers for cancer imaging and therapeutic applications [J].

Berg, K ;

Selbo, PK ;

Weyergang, A ;

Dietze, A ;

Prasmickaite, L ;

Bonsted, A ;

Engesaeter, BO ;

Angell-Petersen, E ;

Warloe, T ;

Frandsen, N ;

Hogset, A .

JOURNAL OF MICROSCOPY, 2005, 218 :133-147

[10] Disulfonated tetraphenyl chlorin (TPCS2a), a novel photosensitizer developed for clinical utilization of photochemical internalization [J].

Berg, Kristian ;

Nordstrand, Solveig ;

Selbo, Pal Kristian ;

Diem Thuy Thi Tran ;

Angell-Petersen, Even ;

Hogset, Anders .

PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES, 2011, 10 (10) :1637-1651

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