PI3K and Chemotaxis: A Priming Issue?

被引：21

作者：

Afonso, Philippe V. ^{[1
]}

Parent, Carole A. ^{[1
]}

机构：

[1] NCI, Cellular & Mol Biol Lab, Ctr Canc Res, NIH, Bethesda, MD 20892 USA

来源：

SCIENCE SIGNALING | 2011年 / 4卷 / 170期

关键词：

NEUTROPHIL CHEMOTAXIS; CHEMOATTRACTANT GRADIENTS; MEDIATES CHEMOTAXIS; CELL-MIGRATION; LEADING-EDGE; 3-KINASE; ACTIVATION; ROLES; DICTYOSTELIUM; PI3K-GAMMA;

D O I：

10.1126/scisignal.2002019

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Although the spatiotemporal activation of phosphoinositide 3-kinases (PI3Ks) at the leading edge of chemotaxing cells represents a key marker of polarity, both Dictyostelium discoideum and neutrophils lacking measurable PI3K activity can still migrate directionally under certain conditions. Evidence from various papers suggests that the differentiation state of cells or their priming status can consolidate otherwise contradictory findings.

引用

页数：3

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