How to facilitate early diagnosis of CNS involvement in malignant lymphoma

被引：11

作者：

Korfel, Agnieszka ^{[1
]}

Nowosielski, Martha ^{[2
]}

Pardo-Moreno, Javier ^{[3
]}

Javier Penalver, Francisco ^{[4
]}

Buda, Gabriele ^{[5
]}

Bennani, Hind ^{[6
]}

Costopoulos, Myrto ^{[7
]}

Le Garff-Tavernier, Magali ^{[7
]}

Soussain, Carole ^{[8
]}

Schmid, Mathias ^{[9
]}

Alberto Orfao, Jose ^{[10
,11
]}

Glantz, Michael ^{[12
]}

机构：

[1] Charite Univ Med Berlin, Dept Hematol Oncol & Tumor Immunol, Hindenburgdamm 30, D-12200 Berlin, Germany

[2] Med Univ Innsbruck, Dept Neurol, Innsbruck, Austria

[3] Univ Hosp King Juan Carlos, Dept Neurol, Madrid, Spain

[4] Univ Hosp Fdn Alcorcon, Dept Hematol, Madrid, Spain

[5] Univ Pisa, Dept Hematol & Oncol, Pisa, Italy

[6] Hop Foch, Dept Biol, Suresnes, France

[7] Hop La Pitie Salpetriere, Dept Biol Hematol, Paris, France

[8] Hop Rene Huguenin, Inst Curie, Dept Hematol, Paris, France

[9] Stadtspital Triemli Zurich, Dept Hematol & Oncol, Zurich, Switzerland

[10] Univ Salamanca, Dept Med, Salamanca, Spain

[11] Univ Salamanca, Cytometry Serv, Salamanca, Spain

[12] Penn State Coll Med, Hershey, PA USA

来源：

EXPERT REVIEW OF HEMATOLOGY | 2016年 / 9卷 / 11期

关键词：

Secondary CNS lymphoma; parenchymal; meningeal; cerebrospinal fluid cytomorphology; cerebrospinal fluid flow cytometry; novel markers; response criteria; neuroaxis MRI; NERVOUS-SYSTEM LYMPHOMA; B-CELL LYMPHOMA; CEREBROSPINAL-FLUID CYTOLOGY; NON-HODGKINS-LYMPHOMA; OCCULT LEPTOMENINGEAL DISEASE; INVERSION-RECOVERY IMAGES; CSF SOLUBLE CD27; DIFFERENTIAL-DIAGNOSIS; FLOW-CYTOMETRY; SOLID TUMORS;

D O I：

10.1080/17474086.2016.1242405

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Introduction: Making the diagnosis of secondary CNS involvement in lymphoma can be difficult due to unspecific signs and symptoms, limited accessibility of brain/myelon parenchyma and low sensitivity and/or specifity of imaging and cerebrospinal fluid (CSF) examination currently available.Areas covered: MRI of the total neuroaxis followed by CSF cytomorphology and flow cytometry are methods of choice when CNS lymphoma (CNSL) is suspected. To reduce the numerous pitfalls of these examinations several aspects should be considered. New CSF biomarkers might be of potential diagnostic value. Attempts to standardize response criteria are presented.Expert commentary: Diagnosing CNSL remains challenging. Until diagnostic methods combining high sensitivity with high specifity are routinely introduced, high level of awareness and optimal utilization of examinations currently available are needed to early diagnose this potentially devastating disease.

引用

页码：1081 / 1091

页数：11

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