Schistosomiasis vaccines: where do we stand?

被引：108
作者：
Tebeje, Biniam Mathewos [1 ,2 ,3 ]
Harvie, Marina [1 ]
You, Hong [1 ]
Loukas, Alex [4 ]
McManus, Donald P. [1 ]
机构：
[1] QIMR Berghofer Med Res Inst, Brisbane, Qld, Australia
[2] Univ Queensland, Sch Publ Hlth, Brisbane, Qld, Australia
[3] Univ Gondar, Dept Immunol & Mol Biol, Sch Biomed & Lab Sci, Coll Med & Hlth Sci, Gondar, Ethiopia
[4] James Cook Univ, Australian Inst Trop Hlth & Med, Ctr Biodiscovery & Mol Dev Therapeut, Cairns, Australia
来源：
PARASITES & VECTORS | 2016年 / 9卷
基金：
英国医学研究理事会;
关键词：
Schistosoma mansoni; Schistosoma haematobium; Schistosoma japonicum; Immune response; Schistosomiasis; Vaccine; Immune protection; Antigen discovery; SM-P80-BASED DNA VACCINE; ACID-BINDING PROTEIN; PROTECTIVE EFFICACY; IMMUNE-RESPONSE; ANTIBODY-RESPONSES; ZOONOTIC SCHISTOSOMIASIS; AND/OR PRAZIQUANTEL; CYTOKINE RESPONSES; PREDICT RESISTANCE; MANSONI INFECTION;
D O I：
10.1186/s13071-016-1799-4
中图分类号：
R38 [医学寄生虫学]; Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ; 100103 ;
摘要：
Schistosomiasis, caused mainly by S. mansoni, S. haematobium and S. japonicum, continues to be a serious tropical disease and public health problem resulting in an unacceptably high level of morbidity in countries where it is endemic. Praziquantel, the only drug currently available for treatment, is unable to kill developing schistosomes, it does not prevent re-infection and its continued extensive use may result in the future emergence of drug-resistant parasites. This scenario provides impetus for the development and deployment of anti-schistosome vaccines to be used as part of an integrated approach for the prevention, control and eventual elimination of schistosomiasis. This review considers the present status of candidate vaccines for schistosomiasis, and provides some insight on future vaccine discovery and design.
引用
收藏
页码：1 / 15
页数：15
相关论文
共 113 条
  • [31] Two SmDLC antigens as potential vaccines against schistosomiasis
    Diniz, Patricia Placona
    Nakajima, Erika
    Miyasato, Patricia Aoki
    Nakano, Eliana
    Rocha, Marcia de Oliveira
    Leme Martins, Elizabeth Angelica
    [J]. ACTA TROPICA, 2014, 140 : 193 - 201
  • [32] Specific humoral response of hosts with variable schistosomiasis susceptibility
    Driguez, Patrick
    McWilliam, Hamish E. G.
    Gaze, Soraya
    Piedrafita, David
    Pearson, Mark S.
    Nakajima, Rie
    Duke, Mary
    Trieu, Angela
    Doolan, Denise L.
    Cardoso, Fernanda C.
    Jasinskas, Algis
    Gobert, Geoffrey N.
    Felgner, Philip L.
    Loukas, Alex
    Meeusen, Els
    McManus, Donald P.
    [J]. IMMUNOLOGY AND CELL BIOLOGY, 2016, 94 (01) : 52 - 65
  • [33] Antibody Signatures Reflect Different Disease Pathologies in Patients With Schistosomiasis Due to Schistosoma japonicum
    Driguez, Patrick
    Li, Yuesheng
    Gaze, Soraya
    Pearson, Mark S.
    Nakajima, Rie
    Trieu, Angela
    Doolan, Denise L.
    Felgner, Philip L.
    Hou, Xunya
    Cardoso, Fernanda C.
    Jasinskas, Algis
    Gobert, Geoffrey N.
    Loukas, Alex
    McManus, Donald P.
    [J]. JOURNAL OF INFECTIOUS DISEASES, 2016, 213 (01) : 122 - 130
  • [34] Clinical implications of recent findings in schistosome proteomics
    Driguez, Patrick
    McManus, Donald P.
    Gobert, Geoffrey N.
    [J]. EXPERT REVIEW OF PROTEOMICS, 2016, 13 (01) : 19 - 33
  • [35] Schistosomiasis vaccine discovery using immunomics
    Driguez, Patrick
    Doolan, Denise L.
    Loukas, Alex
    Felgner, Philip L.
    McManus, Donald P.
    [J]. PARASITES & VECTORS, 2010, 3
  • [36] Cysteine Peptidases as Schistosomiasis Vaccines with Inbuilt Adjuvanticity
    El Ridi, Rashika
    Tallima, Hatem
    Selim, Sahar
    Donnelly, Sheila
    Cotton, Sophie
    Santana, Bibiana Gonzales
    Dalton, John P.
    [J]. PLOS ONE, 2014, 9 (01):
  • [37] Transmission electron microscopic observations on ultrastructural alterations in Schistosoma mansoni adult worms recovered from C57BL/6 mice treated with radiation-attenuated vaccine and/or praziquantel in addition to passive immunization with normal and vaccinated rabbit sera against infection
    El-Shabasy, Eman A.
    Reda, Enayat S.
    Abdeen, Sherif H.
    Said, Ashraf E.
    Ouhtit, Allal
    [J]. PARASITOLOGY RESEARCH, 2015, 114 (04) : 1563 - 1580
  • [38] Combination of the two schistosomal antigens Sm14 and Sm29 elicits significant protection against experimental Schistosoma mansoni infection
    Ewaisha, Radwa E.
    Bahey-El-Din, Mohammed
    Mossallam, Shereen F.
    Amer, Eglal I.
    Aboushleib, Hamida M.
    Khalil, Amal M.
    [J]. EXPERIMENTAL PARASITOLOGY, 2014, 145 : 51 - 60
  • [39] Schistosome Syntenin Partially Protects Vaccinated Mice against Schistosoma mansoni Infection
    Figueiredo, Barbara C.
    Assis, Natan R. G.
    Morais, Suellen B.
    Ricci, Natasha D.
    Pinheiro, Carina S.
    Martins, Vicente P.
    Bicalho, Rodrigo M.
    Da'dara, Akram A.
    Skelly, Patrick J.
    Oliveira, Sergio C.
    [J]. PLOS NEGLECTED TROPICAL DISEASES, 2014, 8 (08):
  • [40] Kicking in the guts: Schistosoma mansoni digestive tract proteins are potential candidates for vaccine development
    Figueiredo, Barbara Castro-Pimentel
    Ricci, Natasha Delaqua
    Goncalves de Assis, Natan Raimundo
    de Morais, Suellen Batistoni
    Fonseca, Cristina Toscano
    Oliveira, Sergio Costa
    [J]. FRONTIERS IN IMMUNOLOGY, 2015, 6
12345678910