Clonally related follicular lymphomas and histiocytic/dendritic cell sarcomas: evidence for transdifferentiation of the follicular lymphoma clone

被引：238

作者：

Feldman, Andrew L. ^{[1
,2
]}

Arber, Daniel A. ^{[3
]}

Pittaluga, Stefania ^{[1
]}

Martinez, Antonio ^{[4
]}

Burke, Jerome S. ^{[5
]}

Raffeld, Mark ^{[1
]}

Camos, Mireia ^{[4
]}

Warnke, Roger ^{[3
]}

Jaffe, Elaine S. ^{[1
]}

机构：

[1] NCI, Pathol Lab, Bethesda, MD 20892 USA

[2] Mayo Clin, Dept Lab Med & Pathol, Rochester, MN USA

[3] Stanford Univ, Dept Pathol, Stanford, CA 94305 USA

[4] Univ Barcelona, Barcelona, Spain

[5] Alta Bates Summit Med Ctr, Dept Pathol, Berkeley, CA USA

来源：

BLOOD | 2008年 / 111卷 / 12期

关键词：

D O I：

10.1182/blood-2007-11-124792

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Rare cases of histiocytic and dendritic cell (H/DC) neoplasms have been reported in patients with follicular lymphoma (FL), but the biologic relationship between the 2 neoplasms is unknown. We studied 8 patients with both FL and H/DC neoplasms using immunohistochemistry, fluorescence in situ hybridization (FISH) for t(14;18), and polymerase chain reaction (PCR)/sequencing of BCL2 and IGH rearrangements. There were 5 men and 3 women (median age, 59 years). All cases of FL were positive for t(14;18). The H/DC tumors included 7 histiocytic sarcomas, 5 of which showed evidence of dendritic differentiation, and 1 interdigitating cell sarcoma. Five H/DC tumors were metachronous, following FL by 2 months to 12 years; tumors were synchronous in 3. All 8 H/DC tumors showed presence of the t(14;18) either by FISH, or in 2 cases by PCR with the major breakpoint region (MBR) probe. PCR and sequencing identified identical IGH gene rearrangements or BCL2 gene breakpoints in all patients tested. All H/DC tumors lacked PAX5, and up-regulation of CEBP beta and PU.1 was seen in all cases tested. These results provide evidence for a common clonal origin of FL and H/DC neoplasms when occurring in the same patient, and suggest that lineage plasticity may occur in mature lymphoid neoplasms.

引用

页码：5433 / 5439

页数：7

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