Adipose Tissue-Derived Mesenchymal Stem/Stromal Cells and Their Contribution to Angiogenic Processes in Tissue Regeneration

被引：64

作者：

Krawczenko, Agnieszka ^{[1
]}

Klimczak, Aleksandra ^{[1
]}

机构：

[1] Polish Acad Sci, Lab Biol Stem & Neoplast Cells, Hirszfeld Inst Immunol & Expt Therapy, R Weigla 12, PL-53114 Wroclaw, Poland

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2022年 / 23卷 / 05期

关键词：

mesenchymal stem cells; MSCs secretome; angiogenesis; tissue regeneration; STEM-CELLS; STROMAL CELLS; IN-VITRO; EXTRACELLULAR VESICLES; THERAPEUTIC TARGETS; SINGLE-CENTER; BONE-MARROW; MICROVESICLES; BIOMARKERS; DELIVERY;

D O I：

10.3390/ijms23052425

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Mesenchymal stem/stromal cells (MSCs) are widely described in the context of their regenerative and immunomodulatory activity. MSCs are isolated from various tissues and organs. The most frequently described sources are bone marrow and adipose tissue. As stem cells, MSCs are able to differentiate into other cell lineages, but they are usually reported with respect to their paracrine potential. In this review, we focus on MSCs derived from adipose tissue (AT-MSCs) and their secretome in regeneration processes. Special attention is given to the contribution of AT-MSCs and their derivatives to angiogenic processes described mainly in the context of angiogenic dysfunction. Finally, we present clinical trials registered to date that concern the application of AT-MSCs and their secretome in various medical conditions.

引用

页数：20

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