T1 Independent, T2* Corrected Chemical Shift Based Fat-Water Separation With Multi-peak Fat Spectral Modeling Is an Accurate and Precise Measure of Hepatic Steatosis

被引:178
作者
Hines, Catherine D. G. [1 ]
Frydrychowicz, Alex [1 ,2 ]
Hamilton, Gavin [3 ]
Tudorascu, Dana L. [4 ]
Vigen, Karl K. [1 ]
Yu, Huanzhou [5 ]
McKenzie, Charles A. [6 ]
Sirlin, Claude B. [3 ]
Brittain, Jean H. [7 ]
Reeder, Scott B. [1 ,8 ,9 ,10 ]
机构
[1] Univ Wisconsin, Dept Radiol, Liver Imaging Res Program, Madison, WI 53792 USA
[2] Univ Hosp Freiburg, Dept Diagnost Radiol & Med Phys, Freiburg, Germany
[3] Univ Calif San Diego, Dept Radiol, Liver Imaging Grp, San Diego, CA 92103 USA
[4] Univ Wisconsin, Waisman Lab Brain Imaging & Behav, Madison, WI 53792 USA
[5] GE Healthcare, Appl Sci Lab, Menlo Pk, CA USA
[6] Univ Western Ontario, Dept Med Biophys, London, ON, Canada
[7] GE Healthcare, Appl Sci Lab, Madison, WI USA
[8] Univ Wisconsin, Dept Med Phys, Madison, WI 53792 USA
[9] Univ Wisconsin, Dept Biomed Engn, Madison, WI 53792 USA
[10] Univ Wisconsin, Dept Med, Madison, WI 53792 USA
关键词
fat quantification; MRI; hepatic steatosis; nonalcoholic fatty liver disease; MR spectroscopy; MAGNETIC-RESONANCE-SPECTROSCOPY; LIVER-DISEASE; QUANTIFICATION; MRI; RECONSTRUCTION; VALIDATION; BIOPSY;
D O I
10.1002/jmri.22514
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
Purpose: To determine the precision and accuracy of hepatic fat-fraction measured with a chemical shift-based MRI fat-water separation method, using single-voxel MR spectroscopy (MRS) as a reference standard. Materials and Methods: In 42 patients, two repeated measurements were made using a T-1-independent, T-2*-corrected chemical shift-based fat-water separation method with multi-peak spectral modeling of fat, and T-2-corrected single voxel MR spectroscopy. Precision was assessed through calculation of Bland-Altman plots and concordance correlation intervals. Accuracy was assessed through linear regression between MRI and MRS. Sensitivity and specificity of MRI fat-fractions for diagnosis of steatosis using MRS as a reference standard were also calculated. Results: Statistical analysis demonstrated excellent precision of MRI and MRS fat-fractions, indicated by 95% confidence intervals (units of absolute percent) of [-2.66%, 2.64%] for single MRI ROI measurements, [-0.81%, 0.80%] for averaged MRI ROI, and [-2.70%, 2.87%] for single-voxel MRS. Linear regression between MRI and MRS indicated that the MRI method is highly accurate. Sensitivity and specificity for detection of steatosis using averaged MRI ROI were 100% and 94%, respectively. The relationship between hepatic fat-fraction and body mass index was examined. Conclusion: Fat-fraction measured with T-1-independent T-2*-corrected MRI and multi-peak spectral modeling of fat is a highly precise and accurate method of quantifying hepatic steatosis.
引用
收藏
页码:873 / 881
页数:9
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