Network dynamics in the tumor microenvironment

The evolutionary path from tumor initiation to metastasis can only be fully understood by considering cancer cells as part of a multi-species ecosystem within the tumor microenvironment. This paper reviews and suggests two important recent trends. Firstly, I review arguments that interactions among diverse cells in the tumor microenvironment create a distinct cellular environment that can confer growth advantages, resist interventions, and allow tumors to remain dormant for long periods. Second, I review and highlight a trend toward data-rich, molecularly detailed, computational models of the tumor microenvironment. I argue that data-driven molecularly detailed tumor microenvironment models can now be built using data from multiple emerging high-throughput technologies, and that such models can pinpoint mechanisms of dysregulation and suggest specific drug targets and follow up experiments. (C) 2014 Elsevier Ltd. All rights reserved.