Prognostic Impact of Central Sleep Apnea in Patients With Heart Failure

Background: Central sleep apnea (CSA) is common in patients with heart failure (BF). Earlier studies investigating the influence of CSA on mortality in BF patients, however, have yielded contradictory results. Methods and Results: In a prospective study involving 267 patients with left ventricular (LV) ejection fractions <= 50%, we performed polysomnography and compared heart transplant free survival rates between patients with no or mild CSA (apnea-hypopnea index [AHI] <= 15/h) and those with moderate CSA (AHI 15.1-30/h) or severe CSA (AHI >30/h). During 43 +/- 18 months' mean follow-up, 67 patients (25%) died and 4 patients (1%) underwent heart transplantation. Multivariate Cox analysis identified age, male sex, chronic kidney disease, and decreased LV ejection fraction, but not moderate CSA or severe CSA, as predictors of transplant-free survival. Conclusions: In patients with stable BF, moderate CSA as well as severe CSA do not appear to predict transplant-free survival independently from confounding factors.