Does post-operative radiotherapy improve the treatment outcomes of intracranial hemangiopericytoma? A retrospective study

被引:19
作者
Xiao, Jianbiao [1 ,2 ]
Xu, Lanwei [3 ]
Ding, Yi [4 ]
Wang, Wei [5 ]
Chen, Fen [6 ]
Zhou, Yangshu [7 ]
Zhang, Fengjiao [8 ]
Zhou, Qiyuan [6 ]
Wu, Xuehui [1 ,2 ]
Li, Junpeng [9 ]
Liang, Li [1 ,2 ]
Jen, Yee-Min [10 ]
机构
[1] Southern Med Univ, Nanfang Hosp, Dept Pathol, Sch Basic Med Sci, 1838 Guangzhoudadao Rd, Guangzhou 510515, Guangdong, Peoples R China
[2] Guangdong Prov Key Lab Mol Tumor Pathol, Guangzhou 510515, Guangdong, Peoples R China
[3] Shandong First Med Univ, Dept Hand & Foot Surg, Shandong Prov Hosp, Jinan, Peoples R China
[4] Southern Med Univ, Nanfang Hosp, Dept Radiat Oncol, Guangzhou, Guangdong, Peoples R China
[5] Gen Hosp Southern Theater Command, Dept Pathol, Peoples Liberat Army China, Guangzhou, Peoples R China
[6] Chenzhou 1 Peoples Hosp, Radiotherapy Ctr, Chenzhou, Hunan, Peoples R China
[7] Southern Med Univ, Zhujiang Hosp, Dept Pathol, Guangzhou, Guangdong, Peoples R China
[8] Shanghai Concord Med Canc Ctr, Dept Radiotherapy, Shanghai, Peoples R China
[9] Gen Hosp Southern Theater Command, Dept Obstet & Gynecol, Peoples Liberat Army China, Guangzhou, Peoples R China
[10] Yee Zen Gen Hosp, Dept Radiat Oncol, 30 Yangxing North Rd, Tao Yuan City, Taiwan
基金
中国国家自然科学基金;
关键词
Intracranial hemangiopericytoma; Post-operative radiotherapy; stereotactic radiosurgery; Intensity modulated radiotherapy; TERM-FOLLOW-UP; MENINGEAL HEMANGIOPERICYTOMA; STEREOTACTIC RADIOSURGERY; RADIATION-THERAPY; RECURRENT; CLASSIFICATION; EXPERIENCE; TUMORS; MANAGEMENT; FEATURES;
D O I
10.1186/s12885-021-08594-x
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Background: Intracranial hemangiopericytoma is a rare disease and surgery is the mainstay treatment. Although postoperative adjuvant radiotherapy is often used, there are no reports comparing different radiotherapy techniques. The purpose of this study is to analyze the impact of post-operative radiotherapy and different radiotherapy technique on the results in patients with intracranial hemangiopericytoma (HPC). Methods: We retrospectively reviewed 66 intracranial HPC patients treated between 1999 and 2019 including 29 with surgery followed by radiotherapy (11 with intensity-modulated radiotherapy (IMRT) and 18 with stereotactic radiosurgery (SRS)) and 37 with surgery alone. Chi-square test was used to compare the clinical characteristic between the groups. The Kaplan-Meier method was used to analyze overall survival (OS) and recurrence-free survival (RFS). Multivariate Cox proportional hazards models were used to examine prognostic factors of survival. We also underwent a matched-pair analysis by using the propensity score method. Results: The crude local control rates were 58.6% in the surgery plus post-operative radiotherapy group (PORT) and 67.6% in the surgery alone group (p = 0.453). In the subgroup analysis of the PORT patients, local controls were 72.7% in the IMRT group and 50% in the SRS group (p = 0.228). The median OS in the PORT and surgery groups were 122 months and 98 months, respectively (p = 0.169). The median RFS was 96 months in the PORT group and 72 months in the surgery alone group (p = 0.714). Regarding radiotherapy technique, the median OS and RFS of the SRS group were not significantly different from those in the IMRT group (p = 0.256, 0.960). The median RFS were 112 and 72 months for pathology grade II and III patients, respectively (p = 0.001). Propensity score matching did not change the observed results. Conclusion: In this retrospective analysis, PORT did not improve the local control rates nor the survivals. The local control rates after IMRT and SRS were similar even though the IMRT technique had a much higher biological dose compared with the SRS technique.
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页数:10
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