The antifungal pipeline: a reality check

被引：565
作者：
Perfect, John R. [1 ]
机构：
[1] Duke Univ, Med Ctr, 200 Trent Dr, Durham, NC 27710 USA
来源：
NATURE REVIEWS DRUG DISCOVERY | 2017年 / 16卷 / 09期
关键词：
IN-VITRO ACTIVITY; INFECTIOUS-DISEASES SOCIETY; BROAD-SPECTRUM ANTIFUNGAL; CELECOXIB DERIVATIVE AR-12; AMPHOTERICIN-B; CRYPTOCOCCUS-NEOFORMANS; CANDIDA-ALBICANS; MURINE MODEL; PRACTICE GUIDELINES; PATHOGENIC FUNGI;
D O I：
10.1038/nrd.2017.46
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Invasive fungal infections continue to appear in record numbers as the immunocompromised population of the world increases, owing partially to the increased number of individuals who are infected with HIV and partially to the successful treatment of serious underlying diseases. The effectiveness of current antifungal therapies - polyenes, flucytosine, azoles and echinocandins (as monotherapies or in combinations for prophylaxis, or as empiric, pre-emptive or specific therapies) - in the management of these infections has plateaued. Although these drugs are clinically useful, they have several limitations, such as off-target toxicity, and drug-resistant fungi are now emerging. New antifungals are therefore needed. In this Review, I discuss the robust and dynamic antifungal pipeline, including results from preclinical academic efforts through to pharmaceutical industry products, and describe the targets, strategies, compounds and potential outcomes.
引用
收藏
页码：603 / 616
页数：14
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