Recombinant food allergens

被引：30

作者：

Lorenz, AR ^{[1
]}

Scheurer, S ^{[1
]}

Haustein, D ^{[1
]}

Vieths, S ^{[1
]}

机构：

[1] Paul Ehrlich Inst, Dept Allergol, D-63225 Langen, Germany

来源：

JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES | 2001年 / 756卷 / 1-2期

关键词：

reviews; food allergy; recombinant food allergen;

D O I：

10.1016/S0378-4347(01)00086-X

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Allergenic (glyco)proteins are the elicitors of food allergies and can cause acute severe hypersensitivity reactions. Recombinant food allergens are available in standardised quantity and constant quality. Therefore, they offer new perspectives to overcome current difficulties in the diagnosis, treatment and investigation of food allergies. This review summarises the expression strategies and characteristics of more than 40 recombinant food allergens that have been produced until today. Their IgE-binding properties are compared to those of their natural counterparts, in addition their application as diagnostic tools, the generation of hypoallergenic recombinant isoforms and mutants for therapeutic purposes, the determination of epitopes and cross-reactive structures are described. (C) 2001 Elsevier Science B.V. All rights reserved.

引用

页码：255 / 279

页数：25

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