Preliminary feasibility and efficacy of text messaging and application-based adherence interventions in adolescents with epilepsy

Objective: Few interventions have been developed to improve treatment adherence in adolescents with epilepsy. The purpose of this study was to test the feasibility and acceptability of text messaging and application-based interventions to improve adolescent antiepileptic drug adherence. It was hypothesized that these interventions would improve adherence and would be feasible and acceptable to adolescents and their caregivers. Methods: Twenty-five adolescents (mean age = 15.7; 52% males) and caregivers were randomized to one of five interventions for one month: 1) adolescent text only, 2) adolescent and caregiver text plus communication, 3) adolescent application only, 4) adolescent and caregiver application plus communication, and 5) epilepsy application for adolescents only. Questionnaires were completed at baseline, posttreatment, and 1-month follow-up. The primary outcome measure was electronically monitored adherence. Results: Results indicated high levels of baseline adherence that contributed to minimal adherence improvements. Adolescents and caregivers reported that text messaging and application-based interventions were feasible and acceptable. Significance: These data highlight that technology-focused adherence interventions are feasible but should likely be targeted to those with demonstrated nonadherence in future clinical trials. (C) 2016 Elsevier Inc. All rights reserved.