Plant-Derived Exosomal MicroRNAs Shape the Gut Microbiota

被引：761

作者：

Teng, Yun ^{[2
]}

Ren, Yi ^{[3
]}

Sayed, Mohammed ^{[4
]}

Hu, Xin ^{[5
]}

Lei, Chao ^{[2
]}

Kumar, Anil ^{[2
]}

Hutchins, Elizabeth ^{[6
]}

Mu, Jingyao ^{[2
]}

Deng, Zhongbin ^{[2
]}

Luo, Chao ^{[2
]}

Sundaram, Kumaran ^{[2
]}

Sriwastva, Mukesh K. ^{[2
]}

Zhang, Lifeng ^{[2
]}

Hsieh, Michael ^{[4
]}

Reiman, Rebecca ^{[4
]}

Haribabu, Bodduluri ^{[2
]}

Yan, Jun ^{[2
]}

Jala, Venkatakrishna Rao ^{[2
]}

Miller, Donald M. ^{[2
]}

Van Keuren-Jensen, Kendall ^{[4
]}

Merchant, Michael L. ^{[7
,8
]}

McClain, Craig J. ^{[1
,9
]}

Park, Juw Won ^{[4
,10
]}

Egilmez, Nejat K. ^{[2
]}

Zhang, Huang-Ge ^{[1
,2
]}

机构：

[1] Robley Rex Vet Affairs Med Ctr, Louisville, KY 40206 USA

[2] Univ Louisville, Dept Microbiol & Immunol, James Graham Brown Canc Ctr, CTRB 309,505 Hancock St, Louisville, KY 40202 USA

[3] Nanjing Med Univ, Dept Breast & Thyroid Surg, Affiliated Huaian Peoples Hosp 1, Huaian 223300, Jiangsu, Peoples R China

[4] Univ Louisville, Dept Comp Engn & Comp Sci, Louisville, KY 40202 USA

[5] Univ Texas MD Anderson Canc Ctr, Dept Genom Med, Houston, TX 77030 USA

[6] Translat Genom Res Inst, Phoenix, AZ 85004 USA

[7] Univ Louisville, Kidney Dis Program, Louisville, KY 40292 USA

[8] Univ Louisville, Clin Prote Ctr, Louisville, KY 40292 USA

[9] Univ Louisville, Sch Med, Dept Med, Div Gastroenterol Hepatol & Nutr, Louisville, KY 40202 USA

[10] Univ Louisville, KBRIN Bioinformat Core, Louisville, KY 40202 USA

来源：

CELL HOST & MICROBE | 2018年 / 24卷 / 05期

基金：

美国国家卫生研究院;

关键词：

INFLAMMATION; INDUCTION; DEFENSE; DIET;

D O I：

10.1016/j.chom.2018.10.001

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The gut microbiota can be altered by dietary interventions to prevent and treat various diseases. However, the mechanisms by which food products modulate commensals remain largely unknown. We demonstrate that plant-derived exosome-like nanoparticles (ELNs) are taken up by the gut microbiota and contain RNAs that alter microbiome composition and host physiology. Ginger ELNs (GELNs) are preferentially taken up by Lactobacillaceae in a GELN lipid-dependent manner and contain microRNAs that target various genes in Lactobacillus rhamnosus (LGG). Among these, GELN mdo-miR7267-3p-mediated targeting of the LGG monooxygenase ycnE yields increased indole-3-carboxaldehyde (I3A). GELN-RNAs or I3A, a ligand for aryl hydrocarbon receptor, are sufficient to induce production of IL-22, which is linked to barrier function improvement. These functions of GELN-RNAs can ameliorate mouse colitis via IL-22-dependent mechanisms. These findings reveal how plant products and their effects on the microbiome may be used to target specific host processes to alleviate disease.

引用

页码：637 / +

页数：24

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