共 98 条
Metal dipyrrin complexes as potential photosensitizers for photodynamic therapy
被引:18
作者:

Karges, Johannes
论文数: 0 引用数: 0
h-index: 0
机构:
PSL Univ, Inst Chem Life & Hlth Sci, Lab Inorgan Chem Biol, Chim ParisTech,CNRS, F-75005 Paris, France PSL Univ, Inst Chem Life & Hlth Sci, Lab Inorgan Chem Biol, Chim ParisTech,CNRS, F-75005 Paris, France

Blacque, Olivier
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Zurich, Dept Chem, Winterthurerstr 190, CH-8057 Zurich, Switzerland PSL Univ, Inst Chem Life & Hlth Sci, Lab Inorgan Chem Biol, Chim ParisTech,CNRS, F-75005 Paris, France

Gasser, Gilles
论文数: 0 引用数: 0
h-index: 0
机构:
PSL Univ, Inst Chem Life & Hlth Sci, Lab Inorgan Chem Biol, Chim ParisTech,CNRS, F-75005 Paris, France PSL Univ, Inst Chem Life & Hlth Sci, Lab Inorgan Chem Biol, Chim ParisTech,CNRS, F-75005 Paris, France
机构:
[1] PSL Univ, Inst Chem Life & Hlth Sci, Lab Inorgan Chem Biol, Chim ParisTech,CNRS, F-75005 Paris, France
[2] Univ Zurich, Dept Chem, Winterthurerstr 190, CH-8057 Zurich, Switzerland
关键词:
Anticancer;
Medicinal inorganic chemistry;
Metals in medicine;
Photodynamic therapy;
RU(II) POLYPYRIDYL COMPLEXES;
BODIPY DYES;
COORDINATION POLYMERS;
ORGANIC FRAMEWORKS;
EXCITED-STATES;
CANCER-CELLS;
FLUORESCENT;
DERIVATIVES;
RUTHENIUM;
BIS;
D O I:
10.1016/j.ica.2020.119482
中图分类号:
O61 [无机化学];
学科分类号:
070301 ;
081704 ;
摘要:
Over the last decades, the use of photodynamic therapy (PDT) for the treatment of various types of cancer as well fungal, viral and bacterial infections has received increasing attention. Despite its clinical success, the currently approved photosensitizers (PSs) are associated with poor water solubility, aggregation, low photostability and a long excretion time. To overcome these limitations, much research is devoted towards the development of PSs based on transition metal complexes. However, the majority of metals used for this purpose are rare and expensive. Therefore, it would be of high interest to develop effective PDT PSs based on cheap and abundant metals. In this article, the use of Cu(II) and Ni(II) dipyrrin complexes as potential PDT PSs against cancer is presented. As required for PDT applications, these complexes were found to have a strong absorption in the green spectrum and to be stable in an aqueous solution in the dark as well as upon light irradiation. Biological studies revealed that the complexes have a very low cytotoxic effect in the dark with a slight effect upon irradiation at 510 nm in human cervical carcinoma (HeLa) cells.
引用
收藏
页数:7
相关论文
共 98 条
[61]
Combination of Ru(II) complexes and light: new frontiers in cancer therapy
[J].
Mari, Cristina
;
Pierroz, Vanessa
;
Ferrari, Stefano
;
Gasser, Gilles
.
CHEMICAL SCIENCE,
2015, 6 (05)
:2660-2686

Mari, Cristina
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Zurich, Dept Chem, CH-8057 Zurich, Switzerland Univ Zurich, Dept Chem, CH-8057 Zurich, Switzerland

Pierroz, Vanessa
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Zurich, Dept Chem, CH-8057 Zurich, Switzerland
Univ Zurich, Inst Mol Canc Res, CH-8057 Zurich, Switzerland Univ Zurich, Dept Chem, CH-8057 Zurich, Switzerland

Ferrari, Stefano
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Zurich, Inst Mol Canc Res, CH-8057 Zurich, Switzerland Univ Zurich, Dept Chem, CH-8057 Zurich, Switzerland

Gasser, Gilles
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Zurich, Dept Chem, CH-8057 Zurich, Switzerland Univ Zurich, Dept Chem, CH-8057 Zurich, Switzerland
[62]
Photoactivated in Vitro Anticancer Activity of Rhenium(I) Tricarbonyl Complexes Bearing Water-Soluble Phosphines
[J].
Marker, Sierra C.
;
MacMillan, Samantha N.
;
Zipfel, Warren R.
;
Li, Zhi
;
Ford, Peter C.
;
Wilson, Justin J.
.
INORGANIC CHEMISTRY,
2018, 57 (03)
:1311-1331

Marker, Sierra C.
论文数: 0 引用数: 0
h-index: 0
机构:
Cornell Univ, Dept Chem & Chem Biol, Ithaca, NY 14853 USA Cornell Univ, Dept Chem & Chem Biol, Ithaca, NY 14853 USA

MacMillan, Samantha N.
论文数: 0 引用数: 0
h-index: 0
机构:
Cornell Univ, Dept Chem & Chem Biol, Ithaca, NY 14853 USA Cornell Univ, Dept Chem & Chem Biol, Ithaca, NY 14853 USA

Zipfel, Warren R.
论文数: 0 引用数: 0
h-index: 0
机构:
Cornell Univ, Dept Biomed Engn, Ithaca, NY 14853 USA Cornell Univ, Dept Chem & Chem Biol, Ithaca, NY 14853 USA

Li, Zhi
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Calif Santa Barbara, Dept Chem & Biochem, Santa Barbara, CA 93106 USA Cornell Univ, Dept Chem & Chem Biol, Ithaca, NY 14853 USA

Ford, Peter C.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Calif Santa Barbara, Dept Chem & Biochem, Santa Barbara, CA 93106 USA Cornell Univ, Dept Chem & Chem Biol, Ithaca, NY 14853 USA

Wilson, Justin J.
论文数: 0 引用数: 0
h-index: 0
机构:
Cornell Univ, Dept Chem & Chem Biol, Ithaca, NY 14853 USA Cornell Univ, Dept Chem & Chem Biol, Ithaca, NY 14853 USA
[63]
Nickel(II) and Copper(II) Complexes of β-Unsubstituted 5,15-Diazaporphyrins and Pyridazine-Fused Diazacorrinoids: Metal-Template Syntheses and Peripheral Functionalizations
[J].
Matano, Yoshihiro
;
Shibano, Tarou
;
Nakano, Haruyuki
;
Imahori, Hiroshi
.
CHEMISTRY-A EUROPEAN JOURNAL,
2012, 18 (20)
:6208-6216

Matano, Yoshihiro
论文数: 0 引用数: 0
h-index: 0
机构:
Kyoto Univ, Grad Sch Engn, Dept Mol Engn, Nishikyo Ku, Kyoto 6158510, Japan Kyoto Univ, Grad Sch Engn, Dept Mol Engn, Nishikyo Ku, Kyoto 6158510, Japan

Shibano, Tarou
论文数: 0 引用数: 0
h-index: 0
机构:
Kyoto Univ, Grad Sch Engn, Dept Mol Engn, Nishikyo Ku, Kyoto 6158510, Japan Kyoto Univ, Grad Sch Engn, Dept Mol Engn, Nishikyo Ku, Kyoto 6158510, Japan

Nakano, Haruyuki
论文数: 0 引用数: 0
h-index: 0
机构:
Kyushu Univ, Grad Sch Sci, Dept Chem, Fukuoka 8128581, Japan Kyoto Univ, Grad Sch Engn, Dept Mol Engn, Nishikyo Ku, Kyoto 6158510, Japan

Imahori, Hiroshi
论文数: 0 引用数: 0
h-index: 0
机构:
Kyoto Univ, Grad Sch Engn, Dept Mol Engn, Nishikyo Ku, Kyoto 6158510, Japan
Kyoto Univ, Inst Integrated Cell Mat Sci WPI iCeMS, Nishikyo Ku, Kyoto 6158510, Japan
Kyoto Univ, Fukui Inst Fundamental Chem, Sakyo Ku, Kyoto 6068103, Japan Kyoto Univ, Grad Sch Engn, Dept Mol Engn, Nishikyo Ku, Kyoto 6158510, Japan
[64]
Metal-based photosensitizers for photodynamic therapy: the future of multimodal oncology?
[J].
McFarland, Sherri A.
;
Mandel, Arkady
;
Dumoulin-White, Roger
;
Gasser, Gilles
.
CURRENT OPINION IN CHEMICAL BIOLOGY,
2020, 56
:23-27

McFarland, Sherri A.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Texas Arlington, Dept Chem & Biochem, Arlington, TX 76019 USA
Univ North Carolina Greensboro, Dept Chem & Biochem, Greensboro, NC 27402 USA Univ Texas Arlington, Dept Chem & Biochem, Arlington, TX 76019 USA

Mandel, Arkady
论文数: 0 引用数: 0
h-index: 0
机构:
Theralase Technol Inc, Toronto, ON, Canada Univ Texas Arlington, Dept Chem & Biochem, Arlington, TX 76019 USA

Dumoulin-White, Roger
论文数: 0 引用数: 0
h-index: 0
机构:
Theralase Technol Inc, Toronto, ON, Canada Univ Texas Arlington, Dept Chem & Biochem, Arlington, TX 76019 USA

Gasser, Gilles
论文数: 0 引用数: 0
h-index: 0
机构:
PSL Univ, Inst Chem Life & Hlth Sci, Lab Inorgan Chem Biol, CNRS,Chim ParisTech, F-75005 Paris, France Univ Texas Arlington, Dept Chem & Biochem, Arlington, TX 76019 USA
[65]
Metal Complexes for Two-Photon Photodynamic Therapy: A Cyclometallated Iridium Complex Induces Two-Photon Photosensitization of Cancer Cells under Near-IR Light
[J].
McKenzie, Luke K.
;
Sazanovich, Igor V.
;
Baggaley, Elizabeth
;
Bonneau, Mickaele
;
Guerchais, Veronique
;
Williams, J. A. Gareth
;
Weinstein, Julia A.
;
Bryant, Helen E.
.
CHEMISTRY-A EUROPEAN JOURNAL,
2017, 23 (02)
:234-238

McKenzie, Luke K.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Sheffield, Dept Oncol & Metab, Sheffield S10 2RX, S Yorkshire, England
Univ Sheffield, Dept Chem, Sheffield S3 7HF, S Yorkshire, England Univ Sheffield, Dept Oncol & Metab, Sheffield S10 2RX, S Yorkshire, England

Sazanovich, Igor V.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Sheffield, Dept Oncol & Metab, Sheffield S10 2RX, S Yorkshire, England
Univ Sheffield, Dept Chem, Sheffield S3 7HF, S Yorkshire, England
Harwell Sci Campus, Didcot OX11 0QX, Oxon, England Univ Sheffield, Dept Oncol & Metab, Sheffield S10 2RX, S Yorkshire, England

Baggaley, Elizabeth
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Sheffield, Dept Chem, Sheffield S3 7HF, S Yorkshire, England Univ Sheffield, Dept Oncol & Metab, Sheffield S10 2RX, S Yorkshire, England

论文数: 引用数:
h-index:
机构:

论文数: 引用数:
h-index:
机构:

Williams, J. A. Gareth
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Durham, Dept Chem, Durham DH1 3LE, England Univ Sheffield, Dept Oncol & Metab, Sheffield S10 2RX, S Yorkshire, England

Weinstein, Julia A.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Sheffield, Dept Chem, Sheffield S3 7HF, S Yorkshire, England Univ Sheffield, Dept Oncol & Metab, Sheffield S10 2RX, S Yorkshire, England

Bryant, Helen E.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Sheffield, Dept Oncol & Metab, Sheffield S10 2RX, S Yorkshire, England Univ Sheffield, Dept Oncol & Metab, Sheffield S10 2RX, S Yorkshire, England
[66]
Structure-activity relationships for ruthenium and osmium anticancer agents - towards clinical development
[J].
Meier-Menches, Samuel M.
;
Gerner, Christopher
;
Berger, Walter
;
Hartinger, Christian G.
;
Keppler, Bernhard K.
.
CHEMICAL SOCIETY REVIEWS,
2018, 47 (03)
:909-928

Meier-Menches, Samuel M.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Vienna, Dept Analyt Chem, Waehringer Str 38, A-1090 Vienna, Austria
Univ Vienna, Res Cluster Translat Canc Therapy Res, Waehringer Str 42, A-1090 Vienna, Austria
Cardiff Univ, Sch Chem, Pk Pl, Cardiff CF10 3AT, S Glam, Wales Univ Vienna, Dept Analyt Chem, Waehringer Str 38, A-1090 Vienna, Austria

Gerner, Christopher
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Vienna, Dept Analyt Chem, Waehringer Str 38, A-1090 Vienna, Austria Univ Vienna, Dept Analyt Chem, Waehringer Str 38, A-1090 Vienna, Austria

论文数: 引用数:
h-index:
机构:

Hartinger, Christian G.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Auckland, Sch Chem Sci, Private Bag 92019, Auckland 1142, New Zealand Univ Vienna, Dept Analyt Chem, Waehringer Str 38, A-1090 Vienna, Austria

Keppler, Bernhard K.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Vienna, Res Cluster Translat Canc Therapy Res, Waehringer Str 42, A-1090 Vienna, Austria
Univ Vienna, Inst Inorgan Chem, Waehringer Str 42, A-1090 Vienna, Austria Univ Vienna, Dept Analyt Chem, Waehringer Str 38, A-1090 Vienna, Austria
[67]
Self-assembly of oligomeric linear dipyrromethene metal complexes
[J].
Miao, Qing
;
Shin, Ji-Young
;
Patrick, Brian O.
;
Dolphin, David
.
CHEMICAL COMMUNICATIONS,
2009, (18)
:2541-2543

Miao, Qing
论文数: 0 引用数: 0
h-index: 0
机构:
Univ British Columbia, Dept Chem, Vancouver, BC V6T 1Z1, Canada Univ British Columbia, Dept Chem, Vancouver, BC V6T 1Z1, Canada

Shin, Ji-Young
论文数: 0 引用数: 0
h-index: 0
机构:
Univ British Columbia, Dept Chem, Vancouver, BC V6T 1Z1, Canada Univ British Columbia, Dept Chem, Vancouver, BC V6T 1Z1, Canada

Patrick, Brian O.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ British Columbia, Dept Chem, Vancouver, BC V6T 1Z1, Canada Univ British Columbia, Dept Chem, Vancouver, BC V6T 1Z1, Canada

Dolphin, David
论文数: 0 引用数: 0
h-index: 0
机构:
Univ British Columbia, Dept Chem, Vancouver, BC V6T 1Z1, Canada Univ British Columbia, Dept Chem, Vancouver, BC V6T 1Z1, Canada
[68]
Phototoxic Activity and DNA Interactions of Water-Soluble Porphyrins and Their Rhenium(I) Conjugates
[J].
Mion, Giuliana
;
Gianferrara, Teresa
;
Bergamo, Alberta
;
Gasser, Gilles
;
Pierroz, Vanessa
;
Rubbiani, Riccardo
;
Vilar, Ramon
;
Leczkowska, Anna
;
Alessio, Enzo
.
CHEMMEDCHEM,
2015, 10 (11)
:1901-1914

Mion, Giuliana
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Trieste, Dept Chem & Pharmaceut Sci, I-34127 Trieste, Italy Univ Trieste, Dept Chem & Pharmaceut Sci, I-34127 Trieste, Italy

Gianferrara, Teresa
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Trieste, Dept Chem & Pharmaceut Sci, I-34127 Trieste, Italy Univ Trieste, Dept Chem & Pharmaceut Sci, I-34127 Trieste, Italy

Bergamo, Alberta
论文数: 0 引用数: 0
h-index: 0
机构:
Callerio Fdn Onlus, I-34127 Trieste, Italy Univ Trieste, Dept Chem & Pharmaceut Sci, I-34127 Trieste, Italy

Gasser, Gilles
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Zurich, Dept Chem, CH-8057 Zurich, Switzerland Univ Trieste, Dept Chem & Pharmaceut Sci, I-34127 Trieste, Italy

Pierroz, Vanessa
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Zurich, Dept Chem, CH-8057 Zurich, Switzerland Univ Trieste, Dept Chem & Pharmaceut Sci, I-34127 Trieste, Italy

Rubbiani, Riccardo
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Zurich, Dept Chem, CH-8057 Zurich, Switzerland Univ Trieste, Dept Chem & Pharmaceut Sci, I-34127 Trieste, Italy

Vilar, Ramon
论文数: 0 引用数: 0
h-index: 0
机构:
Univ London Imperial Coll Sci Technol & Med, Dept Chem, London SW7 2AZ, England Univ Trieste, Dept Chem & Pharmaceut Sci, I-34127 Trieste, Italy

Leczkowska, Anna
论文数: 0 引用数: 0
h-index: 0
机构:
Univ London Imperial Coll Sci Technol & Med, Dept Chem, London SW7 2AZ, England Univ Trieste, Dept Chem & Pharmaceut Sci, I-34127 Trieste, Italy

Alessio, Enzo
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Trieste, Dept Chem & Pharmaceut Sci, I-34127 Trieste, Italy Univ Trieste, Dept Chem & Pharmaceut Sci, I-34127 Trieste, Italy
[69]
Transition Metal Complexes and Photodynamic Therapy from a Tumor-Centered Approach: Challenges, Opportunities, and Highlights from the Development of TLD1433
[J].
Monro, Susan
;
Colon, Katsuya L.
;
Yin, Huimin
;
Roque, John, III
;
Konda, Prathyusha
;
Gujar, Shashi
;
Thummel, Randolph P.
;
Lilge, Lothar
;
Cameron, Colin G.
;
McFarland, Sherri A.
.
CHEMICAL REVIEWS,
2019, 119 (02)
:797-828

Monro, Susan
论文数: 0 引用数: 0
h-index: 0
机构:
Acadia Univ, Dept Chem, Wolfville, NS B4P 2R6, Canada Acadia Univ, Dept Chem, Wolfville, NS B4P 2R6, Canada

Colon, Katsuya L.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ North Carolina Greensboro, Dept Chem & Biochem, Greensboro, NC 27402 USA Acadia Univ, Dept Chem, Wolfville, NS B4P 2R6, Canada

Yin, Huimin
论文数: 0 引用数: 0
h-index: 0
机构:
Acadia Univ, Dept Chem, Wolfville, NS B4P 2R6, Canada Acadia Univ, Dept Chem, Wolfville, NS B4P 2R6, Canada

Roque, John, III
论文数: 0 引用数: 0
h-index: 0
机构:
Univ North Carolina Greensboro, Dept Chem & Biochem, Greensboro, NC 27402 USA Acadia Univ, Dept Chem, Wolfville, NS B4P 2R6, Canada

Konda, Prathyusha
论文数: 0 引用数: 0
h-index: 0
机构:
Dalhousie Univ, Dept Microbiol & Immunol, Halifax, NS B3H 1XS, Canada Acadia Univ, Dept Chem, Wolfville, NS B4P 2R6, Canada

Gujar, Shashi
论文数: 0 引用数: 0
h-index: 0
机构:
Dalhousie Univ, Dept Microbiol & Immunol, Halifax, NS B3H 1XS, Canada
Dalhousie Univ, Dept Pathol, Halifax, NS B3H 1XS, Canada
Dalhousie Univ, Dept Biol, Halifax, NS B3H 1XS, Canada
IWK Hlth Ctr, Ctr Innovat & Collaborat Hlth Serv Res, Halifax, NS B3K 6R8, Canada Acadia Univ, Dept Chem, Wolfville, NS B4P 2R6, Canada

Thummel, Randolph P.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Houston, Dept Chem, Univ Pk, Houston, TX 77204 USA Acadia Univ, Dept Chem, Wolfville, NS B4P 2R6, Canada

Lilge, Lothar
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Hlth Network, Princess Margaret Canc Ctr, 101 Coll St, Toronto, ON M6R 1Z7, Canada Acadia Univ, Dept Chem, Wolfville, NS B4P 2R6, Canada

Cameron, Colin G.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ North Carolina Greensboro, Dept Chem & Biochem, Greensboro, NC 27402 USA Acadia Univ, Dept Chem, Wolfville, NS B4P 2R6, Canada

McFarland, Sherri A.
论文数: 0 引用数: 0
h-index: 0
机构:
Acadia Univ, Dept Chem, Wolfville, NS B4P 2R6, Canada
Univ North Carolina Greensboro, Dept Chem & Biochem, Greensboro, NC 27402 USA
Dalhousie Univ, Dept Pathol, Halifax, NS B3H 1XS, Canada Acadia Univ, Dept Chem, Wolfville, NS B4P 2R6, Canada
[70]
A chiral, heterometallic metal-organic framework derived from a tris(chelate) coordination complex
[J].
Murphy, DL
;
Malachowski, MR
;
Campana, CF
;
Cohen, SM
.
CHEMICAL COMMUNICATIONS,
2005, (44)
:5506-5508

Murphy, DL
论文数: 0 引用数: 0
h-index: 0
机构: Univ Calif San Diego, Dept Chem & Biochem, La Jolla, CA 92093 USA

Malachowski, MR
论文数: 0 引用数: 0
h-index: 0
机构: Univ Calif San Diego, Dept Chem & Biochem, La Jolla, CA 92093 USA

Campana, CF
论文数: 0 引用数: 0
h-index: 0
机构: Univ Calif San Diego, Dept Chem & Biochem, La Jolla, CA 92093 USA

Cohen, SM
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Calif San Diego, Dept Chem & Biochem, La Jolla, CA 92093 USA Univ Calif San Diego, Dept Chem & Biochem, La Jolla, CA 92093 USA