A bactericidal calix[4]arene-based nanoconstruct with amplified NO photorelease

被引：39

作者：

Di Bari, Ivana ^{[1
]}

Picciotto, Roberta ^{[1
]}

Granata, Giuseppe ^{[2
]}

Blanco, Anna R. ^{[3
]}

Consoli, Grazia M. L. ^{[2
]}

Sortino, Salvatore ^{[1
]}

机构：

[1] Dept Drug Sci, Lab Photochem, Viale Andrea Doria 6, I-95125 Catania, Italy

[2] CNR, Inst Biomol Chem, Via P Gaifami 18, I-95126 Catania, Italy

[3] SIFI SpA, Clin Dev, Via Ercole Patti 36, I-95020 Catania, Italy

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2016年 / 14卷 / 34期

关键词：

NITRIC-OXIDE REDUCTASE; FLUTAMIDE; DELIVERY; RELEASE; PHOTOCHEMISTRY; ERADICATION; MECHANISMS; RESISTANCE; CALIXARENE;

D O I：

10.1039/c6ob01305h

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A hydrophobic N-dodecyl-3-(trifluoromethyl)-4-nitrobenzenamine has been synthesized as a suitable NO photodonor and encapsulated in a nanocontainer based on a polycationic calix[ 4] arene derivative, leading to a supramolecular micellar-like nanoassembly ca. 45 nm in diameter. Visible light excitation of this nanoconstruct triggers NO generation with an efficiency remarkably higher than that observed for the free NO photoreleaser. This amplified NO release results in considerable antibacterial activity against Staphylococcus aureus (ATCC 6538) and Pseudomonas aeruginosa (ATCC 9027) as representative Gram positive and Gram negative bacteria, respectively.

引用

页码：8047 / 8052

页数：6

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