An artificial riboflavin receptor prepared by a template analogue imprinting strategy

被引：73

作者：

Manesiotis, P

Hall, AJ

Courtois, J

Irgum, K

Sellergren, B

机构：

[1] Univ Dortmund, Inst Umweltforsch, D-44221 Dortmund, Germany

[2] Umea Univ, Dept Chem, S-90187 Umea, Sweden

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2005年 / 44卷 / 25期

关键词：

hydrogen bonds; imprinting; molecular recognition; receptors; riboflavin;

D O I：

10.1002/anie.200500342

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Chemical Equation Presented) Cheers! Specificity for riboflavin in water-rich media with an affinity on the order found for the corresponding biological receptor, riboflavin binding protein, is shown by a receptor containing a complementary hydrogen bonding array (see picture). Microcalorimetry performed at low receptor concentrations in a solution mimicking an alcoholic beverage indicated the presence of a small but uniform population of high-affinity sites (K > 106 M-1). © 2005 Wiley-VCH Verlag GmbH & Co. KGaA.

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页码：3902 / 3906

页数：5

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