Autotaxin and Breast Cancer: Towards Overcoming Treatment Barriers and Sequelae

被引：28

作者：

Benesch, Matthew G. K. ^{[1
,2
]}

Tang, Xiaoyun ^{[2
]}

Brindley, David N. ^{[2
]}

机构：

[1] Mem Univ Newfoundland, Fac Med, Discipline Surg, St John, NF A1B 3V6, Canada

[2] Univ Alberta, Fac Med & Dent, Dept Biochem, Canc Res Inst Northern Alberta, Edmonton, AB T6G 2S2, Canada

来源：

CANCERS | 2020年 / 12卷 / 02期

关键词：

lysophosphatidic acid; lipid phosphate phosphatases; GLPG1690; chemoresistance; radiotherapy; metastasis; tumor microenvironment; LIPID PHOSPHATE PHOSPHATASE-1; LYSOPHOSPHATIDIC ACID; TUMOR-GROWTH; LYSOPHOSPHOLIPASE-D; THERAPEUTIC TARGET; RADIATION-THERAPY; DRUG-RESISTANCE; ADIPOSE-TISSUE; OVARIAN-CANCER; LUNG FIBROSIS;

D O I：

10.3390/cancers12020374

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

After a decade of intense preclinical investigations, the first in-class autotaxin inhibitor, GLPG1690, has entered Phase III clinical trials for idiopathic pulmonary fibrosis. In the intervening time, a deeper understanding of the role of the autotaxin-lysophosphatidate (LPA)-lipid phosphate phosphatase axis in breast cancer progression and treatment resistance has emerged. Concordantly, appreciation of the tumor microenvironment and chronic inflammation in cancer biology has matured. The role of LPA as a central mediator behind these concepts has been exemplified within the breast cancer field. In this review, we will summarize current challenges in breast cancer therapy and delineate how blocking LPA signaling could provide novel adjuvant therapeutic options for overcoming therapy resistance and adverse side effects, including radiation-induced fibrosis. The advent of autotaxin inhibitors in clinical practice could herald their applications as adjuvant therapies to improve the therapeutic indexes of existing treatments for breast and other cancers.

引用

页数：18

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