Nonspecific interstitial pneumonia: survival is influenced by the underlying cause

被引：59

作者：

Nunes, Hilario ^{[1
,2
]}

Schubel, Kirsten ^{[2
]}

Piver, Diane ^{[3
]}

Magois, Eline ^{[4
]}

Feuillet, Severine ^{[5
]}

Uzunhan, Yurdagul ^{[1
,2
]}

Carton, Zohra ^{[2
]}

Tazi, Abdellatif ^{[5
]}

Levy, Pierre ^{[6
]}

Brillet, Pierre-Yves ^{[3
]}

Nicholson, Andrew G. ^{[7
,8
]}

Kambouchner, Marianne ^{[9
]}

Valeyre, Dominique ^{[1
,2
]}

机构：

[1] Univ Paris 13, Sorbonne Paris Cite, Reponses Cellulaires & Fonct Hypoxie EA2363, Bobigny, France

[2] Hop Avicenne, AP HP, Serv Pneumol, F-93009 Bobigny, France

[3] Hop Avicenne, AP HP, Serv Radiol, F-93009 Bobigny, France

[4] Univ Picardie Jules Verne, Hop Amiens, Serv Pneumol, Amiens, France

[5] Univ Paris Diderot, Sorbonne Paris Cite, Hop St Louis, AP HP,Serv Pneumol, Paris, France

[6] Univ Paris 06, Hop Tenon, AP HP, Dept Sante Publ,INSERM,U707,UMR S 707, Paris, France

[7] Royal Brompton & Harefield NHS Fdn Trust, Dept Histopathol, London, England

[8] Univ London Imperial Coll Sci Technol & Med, NHLI Div, London, England

[9] Hop Avicenne, AP HP, Serv Anat Pathol, F-93009 Bobigny, France

来源：

EUROPEAN RESPIRATORY JOURNAL | 2015年 / 45卷 / 03期

关键词：

LUNG-DISEASE; HYPERSENSITIVITY PNEUMONITIS; HISTOLOGIC PATTERN; PULMONARY-FIBROSIS; REVISED CRITERIA; CLASSIFICATION; POLYMYOSITIS; PROGNOSIS; FEATURES;

D O I：

10.1183/09031936.00148613

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

Idiopathic, nonspecific interstitial pneumonia (NSIP) is most often associated with various clinical disorders, including connective tissue diseases (CTDs) and chronic hypersensitivity pneumonitis (cHP). Emerging evidence also suggests that "idiopathic" NSIP may be the lung manifestation of undifferentiated CTD (UCTD). However, whether or not NSIP outcome is influenced by the underlying cause remains uncertain. This retrospective study included 127 biopsy-proven NSIP patients (65 women, mean +/- SD age 55 +/- 12 years). Survivals were estimated using a Kaplan-Meier curve and compared using the log-rank test. Multivariate analyses were based on a Cox model. 15 (11.8%) patients had cHP, 29 (22.8%) had CTD, 32 (25.2%) satisfied the Kinder criteria for UCTD and 51 (40.1%) had idiopathic NSIP. At the end of follow-up (mean +/- SD 64 +/- 54 months), a difference in survival was observed between aetiological groups (p=0.002). Survival was better for UCTD than for idiopathic NSIP (p=0.020) and similar to that observed for CTD. cHP survival tended to be poorer than that of idiopathic NSIP (p=0.087) and was an independent predictor of mortality (hazard ratio 2.17, 95% CI 1.05-4.47; p=0.035). NSIP outcome is influenced by its cause. cHP exhibits the highest mortality. UCTD does not differ from CTD supporting the concept of autoimmune NSIP, with a prognosis that is better than that of idiopathic NSIP.

引用

页码：746 / 755

页数：10

共 35 条

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