Autophagy and disease: unanswered questions

被引：321

作者：

Yang, Ying ^{[1
,2
]}

Klionsky, Daniel J. ^{[1
,2
]}

机构：

[1] Univ Michigan, Dept Mol Cellular & Dev Biol, Ann Arbor, MI 48109 USA

[2] Univ Michigan, Life Sci Inst, Ann Arbor, MI 48109 USA

来源：

CELL DEATH AND DIFFERENTIATION | 2020年 / 27卷 / 03期

关键词：

CHAPERONE-MEDIATED AUTOPHAGY; GENE PROMOTER; ALPHA-SYNUCLEIN; HUNTINGTONS-DISEASE; PARKINSONS-DISEASE; PROTEIN EXPRESSION; WDR45; MUTATIONS; PRIMARY NEURONS; DEFICIENT MICE; MITOPHAGY;

D O I：

10.1038/s41418-019-0480-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Autophagy is a process in which intracellular components and dysfunctional organelles are delivered to the lysosome for degradation and recycling. Autophagy has various connections to a large number of human diseases, as its functions are essential for cell survival, bioenergetic homeostasis, organism development, and cell death regulation. In the past two decades, substantial effort has been made to identify the roles of autophagy in tumor suppression and promotion, neurodegenerative disorders, and other pathophysiologies. This review summarizes the current advances and discusses the unanswered questions in understanding the involvement of autophagy in pathogenic mechanisms of disease, primarily focusing on cancer and neurodegenerative diseases.

引用

页码：858 / 871

页数：14

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