Matrix-Assisted Laser Desorption Ionization-Time of Flight Mass Spectrometry for Use with Positive Blood Cultures: Methodology, Performance, and Optimization

被引：85
作者：
Faron, Matthew L. [1 ]
Buchan, Blake W. [1 ,2 ]
Ledeboer, Nathan A. [1 ,2 ]
机构：
[1] Med Coll Wisconsin, Milwaukee, WI 53226 USA
[2] Wisconsin Diagnost Labs, Milwaukee, WI 53226 USA
来源：
JOURNAL OF CLINICAL MICROBIOLOGY | 2017年 / 55卷 / 12期
关键词：
antimicrobial susceptibilities; MALDI-TOF MS; bacterial identification; blood culture; diagnostics; MALDI-TOF MS; DIRECT BACTERIAL IDENTIFICATION; RAPID PATHOGEN IDENTIFICATION; DESORPTION/IONIZATION-TIME; STAPHYLOCOCCUS-AUREUS; ANTIMICROBIAL THERAPY; SAMPLE PREPARATION; STREAM INFECTIONS; DISCRIMINATION; MICROORGANISMS;
D O I：
10.1128/JCM.00868-17
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Early initiation of effective antibiotics for septic patients is essential for patient survival. Matrix-assisted desorption ionization-time of flight mass spectrometry (MALDI-TOF MS) has revolutionized clinical microbiology for isolate identification and has the possibility to impact how blood culture testing is performed. This review discusses the various uses of MALDI-TOF MS for the identification and susceptibility testing of positive blood cultures, the performance of these methods, and the outcomes involved with its implementation.
引用
收藏
页码：3328 / 3338
页数：11
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