Multifaceted Role of PARP-1 in DNA Repair and Inflammation: Pathological and Therapeutic Implications in Cancer and Non-Cancer Diseases

被引：168

作者：

Pazzaglia, Simonetta ^{[1
]}

Pioli, Claudio ^{[1
]}

机构：

[1] ENEA, Lab Biomed Technol, I-00123 Rome, Italy

来源：

CELLS | 2020年 / 9卷 / 01期

关键词：

PARP; inflammation; tumor; DNA repair; PARP inhibitors; NF-KAPPA-B; POLY(ADP-RIBOSE) POLYMERASE 1; ADP-RIBOSYLATION; CELL-DEATH; MYOCARDIAL-ISCHEMIA; GENETIC ABLATION; T-CELLS; ACTIVATION; EXPRESSION; INHIBITION;

D O I：

10.3390/cells9010041

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

PARP-1 (poly(ADP-ribose)-polymerase 1), mainly known for its protective role in DNA repair, also regulates inflammatory processes. Notably, defects in DNA repair and chronic inflammation may both predispose to cancer development. On the other hand, inhibition of DNA repair and inflammatory responses can be beneficial in cancer therapy and PARP inhibitors are currently used for their lethal effects on tumor cells. Furthermore, excess of PARP-1 activity has been associated with many tumors and inflammation-related clinical conditions, including asthma, sepsis, arthritis, atherosclerosis, and neurodegenerative diseases, to name a few. Activation and inhibition of PARP represent, therefore, a double-edged sword that can be exploited for therapeutic purposes. In our review, we will discuss recent findings highlighting the composite multifaceted role of PARP-1 in cancer and inflammation-related diseases.

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页数：20

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