Conserved role of nanos proteins in germ cell development

被引：468

作者：

Tsuda, M

Sasaoka, Y

Kiso, M

Abe, K

Haraguchi, S

Kobayashi, S

Saga, Y

机构：

[1] SOKENDAI, Natl Inst Genet, Div Mammalian Dev, Shizuoka 4118540, Japan

[2] Japan Sci & Technol Corp, CREST, Minato Ku, Tokyo 1050011, Japan

[3] RIKEN, Bioresource Ctr, Tsukuba, Ibaraki 3050074, Japan

[4] Shiga Univ Med Sci, Dept Microbiol, Otsu, Shiga 5202192, Japan

[5] Okazaki Natl Res Inst, Natl Inst Basic Biol, Ctr Integrat Biosci, Okazaki, Aichi 4448585, Japan

来源：

SCIENCE | 2003年 / 301卷 / 5637期

关键词：

D O I：

10.1126/science.1085222

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

In Drosophila, maternally supplied Nanos functions in the migration of primordial germ cells (PGCs) into the gonad; in mice, zygotic genes are involved instead. We report the cloning and the functional analyses of nanos2 and nanos3 in mice. These genes are differentially expressed in mouse PGCs. nanos2 is predominantly expressed in male germ cells, and the elimination of this gene results in a complete loss of spermatogonia. However, nanos3 is found in migrating PGCs, and the elimination of this factor results in the complete loss of germ cells in both sexes. Hence, although mice and flies differ in their mechanisms for germ cell specification, there seems to be conserved function for nanos proteins among invertebrates and vertebrates.

引用

页码：1239 / 1241

页数：3

共 15 条

[1] Purification of primordial germ cells from TNAP(beta-geo) mouse embryos using FACS-gal [J].