Cu-Catalyzed C-H Allylation of Benzimidazoles with Allenes

被引：15

作者：

Dong, Yaxi ^{[1
]}

Breit, Bernhard ^{[1
]}

机构：

[1] Albert Ludwigs Univ Freiburg, Inst Organ Chem, D-79104 Freiburg, Germany

来源：

ORGANIC LETTERS | 2021年 / 23卷 / 17期

关键词：

NI-AL; HETEROCYCLES; ACTIVATION; COPPER; HYDROHETEROARYLATION; ALKENYLATION; ALKYLATION; ANNULATION; SWITCH;

D O I：

10.1021/acs.orglett.1c02346

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

CuH-catalyzed intramolecular cyclization and intermolecular allylation of benzimidazoles with allenes have been described. The reaction proceeded smoothly with the catalytic system of Cu(OAc)(2)/Xantphos and catalytic amount of (MeO)(2)MeSiH. This protocol features mild reaction conditions and a good tolerance of substrates bearing electron-withdrawing, electron-donating, or electron-neutral groups. A new catalytic mechanism was proposed for this copper hydride catalytic system.

引用

页码：6765 / 6769

页数：5

共 25 条

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