On the Antimicrobial Activity of Various Peptide-Based Dendrimers of Similar Architecture

被引:17
|
作者
Lind, Tania K. [1 ,2 ,3 ]
Polcyn, Piotr [4 ]
Zielinska, Paulina [4 ]
Cardenas, Marite [1 ,2 ,5 ,6 ]
Urbanczyk-Lipkowska, Zofia [4 ]
机构
[1] Univ Copenhagen, Nanosci Ctr, DK-2100 Copenhagen, Denmark
[2] Univ Copenhagen, Dept Chem, DK-2100 Copenhagen, Denmark
[3] European Spallat Source ESS AS, S-22363 Lund, Sweden
[4] Polish Acad Sci, Inst Organ Chem, PL-01224 Warsaw, Poland
[5] Malmoe Univ, Dept Biomed Sci, S-20500 Malmo, Sweden
[6] Malmoe Univ, Biofilm Res Ctr, S-20500 Malmo, Sweden
来源
MOLECULES | 2015年 / 20卷 / 01期
基金
瑞典研究理事会;
关键词
dendrimers; peptide; antimicrobial; lipids; SUPPORTED LIPID-BILAYERS;
D O I
10.3390/molecules20010738
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Antimicrobial drug resistance is a major human health threat. Among the many attempts to tackle this problem, the synthesis of antimicrobial compounds that mimic natural antimicrobial peptides appears as a promising approach. Peptide-based dendrimers can be designed to have higher potency than natural antimicrobial peptides and at the same time they can evade the bacterial defense system. Novel dendrimers with similar chemical structure but varying potency in terms of minimum inhibitory concentration were designed. The dependency between dendrimer structure and antibacterial activity as well as their capacity to attack model cell membranes was studied. The data suggests that supramolecular structure in terms of charge distribution and amphiphilicity, rather than net charge, is the main driver for disruption of cellular membranes and this correlates well with dendrimer hemolytic activity.
引用
收藏
页码:738 / 753
页数:16
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