Reactive oxygen and nitrogen species, antioxidants and markers of oxidative damage in human blood: Main analytical methods for their determination

被引：135
作者：
Vasconcelos, Sandra Mary Lima [1 ]
Goulart, Marilia Oliveira Fonseca
Moura, Jose Benedito de Franca
Manfredini, Vanusa
Benfato, Mara da Silveira
Kubota, Lauro Tatsuo
机构：
[1] Univ Fed Alagos, Fac Nutr, BR-57072970 Maceio, AL, Brazil
[2] Univ Fed Alagos, Inst Quim & Biotecnol, BR-57072970 Maceio, AL, Brazil
[3] Univ Fed Alagos, Univ Hosp, BR-57072970 Maceio, AL, Brazil
[4] Univ Fed Rio Grande do Sul, Dept Biofis, BR-91501970 Porto Alegre, RS, Brazil
[5] Univ Estadual Campinas, Inst Quim, Dept Quim Analit, BR-13084971 Campinas, SP, Brazil
来源：
QUIMICA NOVA | 2007年 / 30卷 / 05期
关键词：
biomarkers of oxidative stress; oxidative and nitrosative stress; antioxidants;
D O I：
10.1590/S0100-40422007000500046
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
We review here the chemistry of reactive oxygen and nitrogen species, their biological sources and targets; particularly, biomolecules implicated in the redox balance of the human blood. and appraise the analytical methods available for their detection and quantification. Those biomolecules are represented by the enzymatic antioxidant defense machinery, whereas coadjutant reducing protection is provided by several low molecular weight molecules. Biomolecules can be injured by RONS yielding a large repertoire of oxidized products, some of which can be taken as biomarkers of oxidative damage. Their reliable determination is of utmost interest for their potentiality in diagnosis, prevention and treatment of maladies.
引用
收藏
页码：1323 / 1338
页数：16
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