Formulation of vanillin cross-linked chitosan nanoparticles and its characterization

被引：18

作者：

Wang, Guang ^{[1
]}

Li, Puwang ^{[1
]}

Peng, Zheng ^{[1
]}

Huang, Maofang ^{[1
]}

Kong, Lingxue ^{[2
]}

机构：

[1] Chinese Acad Trop Agr Sci, Agr Prod Proc Res Inst, Zhanjiang 524001, Peoples R China

[2] Deakin Univ, Ctr Mat & Fiber Innovat, Geelong, Vic 3217, Australia

来源：

ADVANCED MATERIALS AND STRUCTURES, PTS 1 AND 2 | 2011年 / 335-336卷

关键词：

Chitosan; Vanillin; Nanoparticles; Cross-linker; DRUG-DELIVERY; IN-VITRO; RELEASE; GLUTARALDEHYDE; MICROSPHERES; BEADS;

D O I：

10.4028/www.scientific.net/AMR.335-336.474

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

Chitosan nanoparticles were successfully prepared by chemical cross-linking with vanillin. The nanoparticles were spherical in shape with smooth surface, and the average particle size of chitosan nanoparticles was 141 nm. The formulation of chitosan nanoparticles is based on Shiff reaction between aldehyde group of vanillin and amino group of chitosan. Chitosan nanoparticles prepared by crosslinking with vanillin are promising vehicle for the drug delivery of various anticancer drugs in the chemotherapy of cancers.

引用

页码：474 / +

页数：2

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